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The Orthogonally Partitioned EM Algorithm: Extending the EM Algorithm for Algorithmic Stability and Bias Correction Due to Imperfect Data

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  • Regier Michael D.

    (Department of Biostatistics, West Virginia University, Morgantown, WV, USA)

  • Moodie Erica E. M.

    (Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, Canada)

Abstract

We propose an extension of the EM algorithm that exploits the common assumption of unique parameterization, corrects for biases due to missing data and measurement error, converges for the specified model when standard implementation of the EM algorithm has a low probability of convergence, and reduces a potentially complex algorithm into a sequence of smaller, simpler, self-contained EM algorithms. We use the theory surrounding the EM algorithm to derive the theoretical results of our proposal, showing that an optimal solution over the parameter space is obtained. A simulation study is used to explore the finite sample properties of the proposed extension when there is missing data and measurement error. We observe that partitioning the EM algorithm into simpler steps may provide better bias reduction in the estimation of model parameters. The ability to breakdown a complicated problem in to a series of simpler, more accessible problems will permit a broader implementation of the EM algorithm, permit the use of software packages that now implement and/or automate the EM algorithm, and make the EM algorithm more accessible to a wider and more general audience.

Suggested Citation

  • Regier Michael D. & Moodie Erica E. M., 2016. "The Orthogonally Partitioned EM Algorithm: Extending the EM Algorithm for Algorithmic Stability and Bias Correction Due to Imperfect Data," The International Journal of Biostatistics, De Gruyter, vol. 12(1), pages 65-77, May.
  • Handle: RePEc:bpj:ijbist:v:12:y:2016:i:1:p:65-77:n:8
    DOI: 10.1515/ijb-2015-0016
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    References listed on IDEAS

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    1. Amy L. Stubbendick & Joseph G. Ibrahim, 2003. "Maximum Likelihood Methods for Nonignorable Missing Responses and Covariates in Random Effects Models," Biometrics, The International Biometric Society, vol. 59(4), pages 1140-1150, December.
    2. James R. Carpenter & Michael G. Kenward & Stijn Vansteelandt, 2006. "A comparison of multiple imputation and doubly robust estimation for analyses with missing data," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 169(3), pages 571-584, July.
    3. D. Oakes, 1999. "Direct calculation of the information matrix via the EM," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 61(2), pages 479-482, April.
    4. Joseph G. Ibrahim & Ming-Hui Chen & Stuart R. Lipsitz, 1999. "Monte Carlo EM for Missing Covariates in Parametric Regression Models," Biometrics, The International Biometric Society, vol. 55(2), pages 591-596, June.
    5. Erica Moodie & D. Stephens, 2011. "Marginal Structural Models: unbiased estimation for longitudinal studies," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 56(1), pages 117-119, February.
    6. Wei Liu & Lang Wu, 2007. "Simultaneous Inference for Semiparametric Nonlinear Mixed-Effects Models with Covariate Measurement Errors and Missing Responses," Biometrics, The International Biometric Society, vol. 63(2), pages 342-350, June.
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