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High Serum Levels of IL-6 Are Associated with Suicide Attempt but Not with High Lethality Suicide Attempts: A Preliminary Case–Control Study

Author

Listed:
  • Rosa Giannina Castillo-Avila

    (División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa 86100, Mexico
    These authors contributed equally to this work.)

  • Alma Delia Genis-Mendoza

    (Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de Mexico 14610, Mexico
    These authors contributed equally to this work.)

  • Isela Esther Juárez-Rojop

    (División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa 86100, Mexico)

  • María Lilia López-Narváez

    (Hospital Chiapas Nos Une “Dr. Gilberto Gómez Maza”, Secretaría de Salud, Tuxtla Gutierrez 29045, Mexico)

  • Diana María Dionisio-García

    (División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa 86100, Mexico)

  • Germán Alberto Nolasco-Rosales

    (División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa 86100, Mexico)

  • Miguel Ángel Ramos-Méndez

    (División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa 86100, Mexico)

  • Yazmín Hernández-Díaz

    (División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Mendez 86040, Mexico)

  • Carlos Alfonso Tovilla-Zárate

    (División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco 86040, Mexico)

  • Thelma Beatriz González-Castro

    (División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Mendez 86040, Mexico)

  • Humberto Nicolini

    (Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de Mexico 14610, Mexico)

Abstract

Suicide attempts are an emerging health problem around the world. Increased levels of IL-6 have been associated with suicidal behavior. Therefore, the aims of this study were to evaluate the serum levels of IL-6 in individuals with suicide attempts and a comparison group and to associate the IL-6 levels with the lethality of the suicide attempt. Additionally, we associated the rs2228145 polymorphism of the IL6R gene with suicide attempts or with the IL-6 serum levels. Suicide attempts and their lethality were evaluated using the Columbia Suicide Severity Rating Scale. The serum concentrations of IL-6 were measured by the ELISA technique in individuals with suicide attempts and then compared to a control group. The rs2228145 polymorphism of the IL6R gene was analyzed by real-time polymerase chain reaction. We found elevated serum levels of IL-6 in the suicide attempt group when compared to the control group (F = 10.37, p = 0.002). However, we found no differences of the IL-6 levels between high and low lethality. The IL6R gene polymorphism rs2479409 was not associated with suicide attempts. Our data suggest that IL-6 serum is increased in individuals with suicide attempts.

Suggested Citation

  • Rosa Giannina Castillo-Avila & Alma Delia Genis-Mendoza & Isela Esther Juárez-Rojop & María Lilia López-Narváez & Diana María Dionisio-García & Germán Alberto Nolasco-Rosales & Miguel Ángel Ramos-Ménd, 2022. "High Serum Levels of IL-6 Are Associated with Suicide Attempt but Not with High Lethality Suicide Attempts: A Preliminary Case–Control Study," IJERPH, MDPI, vol. 19(22), pages 1-12, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:22:p:14735-:d:967883
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    References listed on IDEAS

    as
    1. Silke Bachmann, 2018. "Epidemiology of Suicide and the Psychiatric Perspective," IJERPH, MDPI, vol. 15(7), pages 1-23, July.
    2. Yolanda Mejías-Martín & Juan de Dios Luna del Castillo & Candela Rodríguez-Mejías & Celia Martí-García & Juan Pablo Valencia-Quintero & María Paz García-Caro, 2019. "Factors Associated with Suicide Attempts and Suicides in the General Population of Andalusia (Spain)," IJERPH, MDPI, vol. 16(22), pages 1-13, November.
    Full references (including those not matched with items on IDEAS)

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    Keywords

    suicide attempt; IL-6; serum; polymorphism; IL6R gene; lethality;
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