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Humanistic and Economic Burden of IgA Nephropathy: Systematic Literature Reviews and Narrative Synthesis

Author

Listed:
  • Kenar D. Jhaveri

    (Donald and Barbara Zucker School of Medicine at Hofstra/Northwell)

  • Mark E. Bensink

    (Travere Therapeutics, Inc.)

  • Martin Bunke

    (C M Bunke Consulting)

  • Jonathon A. Briggs

    (Genesis Research)

  • David M. W. Cork

    (Genesis Research)

  • Anushya Jeyabalan

    (Massachusetts General Hospital)

Abstract

Background Immunoglobulin A nephropathy (IgAN) is a progressive inflammatory kidney disease requiring long-term treatment to reduce the risk of progression to kidney failure. Here, we present two systematic literature reviews (SLRs) to identify and summarize literature reporting the humanistic and economic burden of IgAN. Methods Electronic literature databases (Ovid Embase, PubMed, and Cochrane) were searched for relevant literature on 29 November 2021, supplemented with gray literature searches. Studies reporting any health-related quality of life (HRQoL) or health state utility outcomes in IgAN patients were included in the humanistic impact SLR, and studies reporting the costs and healthcare resource utilization associated with or economic models of IgAN disease management were included in the economic burden SLR. Narrative synthesis was used to discuss the heterogeneous studies included in the SLRs. Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and Cochrane guidelines were followed, and all included studies were assessed for risk of bias using the Center for Evidence-Based Management tool for Critical Appraisal of a Survey or the Drummond Checklist. Results A total of 876 and 1122 references were identified from electronic and gray literature searches for humanistic and economic burden, respectively. Three studies reporting humanistic impact and five studies reporting economic burden met criteria for inclusion in these SLRs. The included humanistic studies reported patient preferences in the USA and China, HRQoL for patients with IgAN in Poland, and impact of exercise on HRQoL for patients with IgAN in China. The five economic studies reported costs of IgAN treatment in Canada, Italy, and China, along with two economic models from Japan. Discussion Current literature suggests IgAN is associated with substantial humanistic and economic burdens. However, these SLRs demonstrate the paucity of research conducted to specifically describe the humanistic or economic burden of IgAN and highlight the need for further research.

Suggested Citation

  • Kenar D. Jhaveri & Mark E. Bensink & Martin Bunke & Jonathon A. Briggs & David M. W. Cork & Anushya Jeyabalan, 2023. "Humanistic and Economic Burden of IgA Nephropathy: Systematic Literature Reviews and Narrative Synthesis," PharmacoEconomics - Open, Springer, vol. 7(5), pages 709-722, September.
    • Handle: RePEc:spr:pharmo:v:7:y:2023:i:5:d:10.1007_s41669-023-00415-0
    DOI: 10.1007/s41669-023-00415-0
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    References listed on IDEAS

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    1. Kevin Marsh & Kerrie-Anne Ho & Rachel Lo & Nancy Zaour & Aneesh Thomas George & Nigel S. Cook, 2021. "Assessing Patient Preferences in Rare Diseases: Direct Preference Elicitation in the Rare Chronic Kidney Disease, Immunoglobulin A Nephropathy," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 14(6), pages 837-847, November.
    2. Drummond, Michael F. & Sculpher, Mark J. & Claxton, Karl & Stoddart, Greg L. & Torrance, George W., 2015. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 4, number 9780199665884.
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