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Albumin infusion ameliorates liver injury in streptozotocin-induced diabetic rats

Author

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  • CS Bae

    (College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea)

  • T Ahn

    (College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea)

Abstract

We investigated the effect of an albumin infusion on the enzyme activity, expression level of cytochrome P450 2E1 (CYP2E1), and oxidative stress in the serum and liver of streptozotocin (STZ)-induced diabetic rats. The STZ treatment enhanced the alanine aminotransferase and aspartate aminotransferase activities in the rat serum compared with those in the untreated rats. Treatment with STZ elevated the expression and catalytic activity of CYP2E1, and the oxidative stress, and decreased the reducing potentials in the liver, suggesting the possibility of diabetes-induced liver injury. Moreover, the antioxidant activity of the serum albumin decreased in the diabetic rats. In contrast, the administration of purified albumin from the intact rats to the diabetic rats restored these deleterious liver indices in an albumin concentration-dependent manner. These results suggest that an exogenous albumin infusion alleviates liver damage induced by type 1 diabetes.

Suggested Citation

  • CS Bae & T Ahn, 2022. "Albumin infusion ameliorates liver injury in streptozotocin-induced diabetic rats," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 67(5), pages 245-256.
    • Handle: RePEc:caa:jnlvet:v:67:y:2022:i:5:id:14-2021-vetmed
    DOI: 10.17221/14/2021-VETMED
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    Keywords

    cytochrome P450 2E1; diabetes; oxidative stress;
    All these keywords.

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