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Celastrol Mediated Hsp90 Protein Inhibition in Cancer

Author

Listed:
  • Dharambir Kashyap
  • Hardeep Singh Tuli

    (Department of Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), India
    Department of Biotechnology, Maharishi Markandeshwar University, India)

Abstract

In 2012, according to the globocan data 14.2 million new cases of cancer and 8.2 million cancer associated deaths had been reported. Lack of knowledge in cancer biology has major role for such disaster which increasing the enthusiasm to come up with promising anti-cancer therapy [1]. Discovery of new drug targets in cancer cell urgently required to reduce the mortality and to increase survival rate. The aberrant expression of Heat shock protein (Hsp) 90 has been correlated in all the cancer processes such as cell cycle arrest, angiogenesis, and metastasis [2-8]. So, identification of Hsp90 function in tumor cell may really be helpful which could serve as prognosis biomarker. The Hsp90 is a major molecular chaperone abundantly expressed in all cell types and plays pivotal role in correct folding and functionality of client proteins [9,10].

Suggested Citation

  • Dharambir Kashyap & Hardeep Singh Tuli, 2018. "Celastrol Mediated Hsp90 Protein Inhibition in Cancer," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 5(1), pages 5-7, february.
    • Handle: RePEc:adp:jgjpps:v:5:y:2018:i:1:p:5-7
    DOI: 10.19080/GJPPS.2018.05.555652
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