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Tofacitinib Treatment in Refractory Systemic Lupus Erythematosus with Shrinking Lung Syndrome- A Case-Based Review

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  • Yongmei Han

    (Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, China)

Abstract

Shrinking Lung Syndrome (SLS) is a rare pulmonary complication of Systemic Lupus Erythematosus (SLE), which mainly manifests as dyspnea, pleural chest pain, and restrictive ventilation dysfunction, with or without an elevated hemi-diaphragm. Currently, there is no unified diagnostic criteria for SLS. SLS is a diagnosis of exclusion and can be diagnosed only in the absence of interstitial, alveolar and pulmonary vascular disease. The treatment is based on high-dose glucocorticoids and immunosuppressants. Here, we report a case of a 35-year-old woman who was diagnosed with SLE in 2008. Four years later, she was diagnosed with SLS due to chest pain, dyspnea, cough, and restrictive ventilatory dysfunction.

Suggested Citation

  • Yongmei Han, 2024. "Tofacitinib Treatment in Refractory Systemic Lupus Erythematosus with Shrinking Lung Syndrome- A Case-Based Review," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 54(2), pages 45779-45786, January.
    • Handle: RePEc:abf:journl:v:54:y:2023:i:2:p:45779-45786
    DOI: 10.26717/BJSTR.2024.54.008533
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