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Clinical Pharmacology of Imipenem/Cilastatin

Author

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  • Gian Maria Pacifici

    (Professor of Pharmacology, via Sant’Andrea 32, 56127 Pisa, Italy)

Abstract

Imipenem is a β-lactam antibiotic and is market in combination with cilastatin a drug that inhibits the degradation of imipenem by renal tubular dipeptidase and extends the elimination half-life of imipenem. Imipenem binds to penicillin-binding proteins, disrupts bacterial cell wall synthesis, and causes depth of susceptible organisms. Imipenem is resistant to hydrolysis by most β-lactamases and is active against a wide variety of aerobic and anaerobic microorganisms. Streptococci (including penicillinase-resistant Streptococcus pneumoniae), Enterococcus faecalis, staphylococci (including penicillinase-producing strains but not methicillin-resistant Staphylococcus aureus).

Suggested Citation

  • Gian Maria Pacifici, 2023. "Clinical Pharmacology of Imipenem/Cilastatin," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 53(3), pages 44636-44648, October.
    • Handle: RePEc:abf:journl:v:53:y:2023:i:3:p:44636-44648
    DOI: 10.26717/BJSTR.2023.53.008393
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