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A Systematic Review and Critical Assessment of Health State Utilities: Weight Change and Type 2 Diabetes Mellitus

  • Scott Doyle

    (Oxford Outcomes, Oxford, UK; Health Economics Research Centre, Department of Public Health, University of Oxford, Oxford, UK)

  • Andrew Lloyd

    (Oxford Outcomes, Oxford, UK)

  • Lee Moore

    (Roche Products Ltd., Welwyn Garden City, UK)

  • Joshua Ray

    (F. Hoffmann-La Roche Ltd., Basel, Switzerland)

  • Alastair Gray

    (Health Economics Research Centre, Department of Public Health, University of Oxford, Oxford, UK)

Objective:Objective: The study aimed to conduct a systematic literature search to identify health state utilities for weight change in type 2 diabetes mellitus (T2DM) and to review those values for appropriateness for inclusion in a submission to the National Institute for Health and Clinical Excellence (NICE). Abstract: Methods:Methods: The search was conducted using keywords and Medical Subject Heading (MeSH) terms designed to exhaustively capture health state utility values across a variety of known economic, health technology assessment and peer-reviewed publication databases. The values were then critically reviewed from the perspective of the NICE reference case (2008 methods guide). Abstract: Results:Results: The search resulted in a large number of repeat references across databases suggesting good sensitivity. Thirty-three articles were selected for inclusion and subjected to a critical review including their methodological quality, symmetry with the NICE reference case, sample size and country source. This critical review led to a shortlist of nine utility studies, all of which had potential for inclusion in cost-utility models or a meta-analysis. Abstract: Conclusions:Conclusions: A relatively large number of utilities have been collected in weight change and T2DM. Many of these utility values are not suitable for inclusion in a NICE submission. A better way of reviewing the methodological quality of utilities is needed.

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Article provided by Springer Healthcare | Adis in its journal PharmacoEconomics.

Volume (Year): 30 (2012)
Issue (Month): 12 ()
Pages: 1133-1143

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Handle: RePEc:wkh:phecon:v:30:y:2012:i:12:p:1133-1143
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