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Modelling the Budget Impact of Darunavir in the Treatment of Highly Treatment-Experienced, HIV-Infected Adults in France

  • Xavier Colin

    (Cemka-Eval, 43 Boulevard du Marchal Joffre, 92340 Bourg-la-Reine, France)

  • Antoine Lafuma

    (Cemka-Eval, 43 Boulevard du Marchal Joffre, 92340 Bourg-la-Reine, France)

  • Dominique Costagliola

    (INSERM, Unit Mixte de Recherche (UMR) S 720, and Universit Pierre et Marie Curie-Paris 6, UMR S 720, Paris, France)

  • Erik Smets

    (Johnson Johnson Pharmaceutical Services LLC, Mechelen, Belgium)

  • Josephine Mauskopf

    (RTI HEALTH Solutions, Research Triangle Park, North Carolina, USA)

  • Pascal Guillon

    (Janssen Cilag SAS, Issy les Moulineaux, France)

Registered author(s):

    Background: A key element for payers in the assessment of the economic profile of a medication is its anticipated impact on the evolution of healthcare budgets. Objectives: To forecast the impact of the use of darunavir with low-dose ritonavir 600/100 mg twice a day (bid) in highly treatment-experienced, HIV-infected adults who have failed one or more protease inhibitor (PI)-containing regimen on the budget of the French Sickness Fund (French healthcare system) over a 3-year time horizon. Methods: A transition state model based on disease severity was developed that compared the evolution of antiretroviral and non-antiretroviral-related direct costs of care in the target population over 3 years (2007-2009) under two scenarios: (1) darunavir enters the French market in year 1; (2) darunavir is not available to the target population during 2007-2009. Model inputs were derived from a targeted analysis of the French hospital database in HIV, the darunavir POWER 1 and 2 trials and other relevant clinical studies. Results: In the scenario where darunavir was available from year 1, the proportion of patients in the lower, more costly CD4 cell count strata (≤100 cells per mm) was consistently lower than in the scenario without darunavir in each year of the model (17.0% vs 19.2%, 13.9% vs 18.3% and 10.8% vs 16.8% for years 1, 2 and 3, respectively). As a result, over the entire 3-year period, the net increase of antiretroviral drug costs (+5.6 million Euros; &U20AC;), resulting from the substitution of older, cheaper PIs by darunavir, is expected to be fully compensated by savings in hospitalization costs (&U20AC;-9.7 million) and expenditures for other HIV-related (non-antiretroviral) medications (&U20AC;-7.3 million), leading to a net saving of &U20AC;11.4 million or 2.9% of the total budget in the scenario without darunavir. Various sensitivity analyses confirmed these projected savings. Conclusion: The use of darunavir/ritonavir (DRV/r) 600/100 mg bid, in combination with other antiretroviral agents, in highly pre-treated, HIV-infected adults who have failed one or more PI-containing highly active antiretroviral therapy regimen is not expected to increase the budget of the French healthcare system, in comparison with a scenario without darunavir. Further research is needed to estimate the budget impact of the use of DRV/r in less treatment-experienced, HIV-infected individuals in France.

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    Article provided by Springer Healthcare | Adis in its journal PharmacoEconomics.

    Volume (Year): 28 (2010)
    Issue (Month): S1 ()
    Pages: 183-197

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    Handle: RePEc:wkh:phecon:v:28:y:2010:i:s1:p:183-197
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