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Preconception diabetes mellitus and adverse pregnancy outcomes in over 6.4 million women: A population-based cohort study in China

Author

Listed:
  • Yumei Wei
  • Qin Xu
  • Huixia Yang
  • Ying Yang
  • Long Wang
  • Huan Chen
  • Craig Anderson
  • Xinyue Liu
  • Geng Song
  • Qian Li
  • Qiaomei Wang
  • Haiping Shen
  • Yiping Zhang
  • Donghai Yan
  • Zuoqi Peng
  • Yuan He
  • Yuanyuan Wang
  • Ya Zhang
  • Hongguang Zhang
  • Xu Ma

Abstract

Background: Diabetes mellitus (DM) increases the risk of adverse maternal and neonatal outcomes, and optimization of glycemic control during pregnancy can help mitigate risks associated with diabetes. However, studies seldom focus precisely on maternal blood glucose level prior to pregnancy. We aimed to evaluate the associations between preconception blood fasting plasma glucose (FPG) level and subsequent pregnancy outcomes. Methods and findings: We conducted a population-based retrospective cohort study among 6,447,339 women aged 20–49 years old who participated in National Free Pre-Pregnancy Checkups Project and completed pregnancy outcomes follow-up between 2010 and 2016 in China. During the preconception health examination, serum FPG concentration was measured, and self-reported history of DM was collected. Women were classified into three groups (normal FPG group: FPG

Suggested Citation

  • Yumei Wei & Qin Xu & Huixia Yang & Ying Yang & Long Wang & Huan Chen & Craig Anderson & Xinyue Liu & Geng Song & Qian Li & Qiaomei Wang & Haiping Shen & Yiping Zhang & Donghai Yan & Zuoqi Peng & Yuan , 2019. "Preconception diabetes mellitus and adverse pregnancy outcomes in over 6.4 million women: A population-based cohort study in China," PLOS Medicine, Public Library of Science, vol. 16(10), pages 1-15, October.
    • Handle: RePEc:plo:pmed00:1002926
    DOI: 10.1371/journal.pmed.1002926
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