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Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519

Author

Listed:
  • Dong Wang

    (University of Minnesota)

  • Fan Bu

    (University of Minnesota
    University of Minnesota Medical School)

  • Ge Yang

    (University of Minnesota)

  • Bin Liu

    (University of Minnesota)

Abstract

ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding pocket in the RdRp palm subdomain that overlaps the catalytic GDN motif. These findings clarify the basis of resistance mutations, including W671, and provide a foundation for designing next-generation Paramyxovirus antivirals.

Suggested Citation

  • Dong Wang & Fan Bu & Ge Yang & Bin Liu, 2025. "Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519," Nature Communications, Nature, vol. 16(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64128-0
    DOI: 10.1038/s41467-025-64128-0
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    References listed on IDEAS

    as
    1. Fernanda A. Sala & Katja Ditter & Olexandr Dybkov & Henning Urlaub & Hauke S. Hillen, 2025. "Structural basis of Nipah virus RNA synthesis," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    2. Fernanda A. Sala & Katja Ditter & Olexandr Dybkov & Henning Urlaub & Hauke S. Hillen, 2025. "Author Correction: Structural basis of Nipah virus RNA synthesis," Nature Communications, Nature, vol. 16(1), pages 1-1, December.
    3. Dong Wang & Ge Yang & Bin Liu, 2025. "Structure of the measles virus ternary polymerase complex," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    4. Ge Yang & Dong Wang & Bin Liu, 2024. "Structure of the Nipah virus polymerase phosphoprotein complex," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    5. Qi Peng & Yingying Dong & Mingzhu Jia & Qiannv Liu & Yuhai Bi & Jianxun Qi & Yi Shi, 2024. "Cryo-EM structure of Nipah virus L-P polymerase complex," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

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