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Synthesis and Study of 1,2,4-Triazine and Thiadiazoles Based Derivatives of S-Triazine as Antimicrobial Agents

Author

Listed:
  • G. M. Malik

    (Department of Chemistry, Navyug Science College, Surat, Gujarat, India)

  • Talha V.Patel.

    (Department of Chemistry, Navyug Science College, Surat, Gujarat, India)

Abstract

Some new substituted 1,3,5 triazine derivatives with 4-amino-6-(tert-butyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one and 5-benzyl-1,3,4-thiadiazol-2-amine and primary amine were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains using a micro dilution procedure. Synthesized compounds P1BF to P15BF prove to be effective with MIC ( g/mL), among them P2BF, P6BF, P15BF showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, 1H-NMR, 13CNMR, MASS Analysis.

Suggested Citation

  • G. M. Malik & Talha V.Patel., 2017. "Synthesis and Study of 1,2,4-Triazine and Thiadiazoles Based Derivatives of S-Triazine as Antimicrobial Agents," Journal of Asian Scientific Research, Asian Economic and Social Society, vol. 7(6), pages 214-223, June.
  • Handle: RePEc:asi:joasrj:2017:p:214-223
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