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Comparative Study of Degree of Low Grade Chronic Inflammatory Status in Freshly Diagnosed Type 1 with Type 2 Diabetic Patients


  • Shamim Shaikh Mohiuddin

    (Department of Biochemistry, College of Medicine, Imam Abdulrahman Bin Faisal University, Kingdom of Saudi Arabia)

  • Poornima Manjrekar

    (Department of Biochemistry, kasturba Medical College, Manipal University, Mangalore, India)


Low grade inflammatory condition which is predominately cytokine-mediated is observed to be closely involved in the pathogenesis of type 2 diabetes as well as role this inflammatory condition cannot be ruled out in involvement in pathogenesis of type 1 diabetes. Since maximum world populations are at high risk of developing diabetes, we tested this hypothesis by estimating circulating acute phase proteins in freshly diagnosed type 2 (T-2) as well as type1(T-1) diabetic patients. The acute phase proteins, α1- antitrypsin, α1- acid glycoprotein, ceruloplasmin and fibrinogen were estimated in the plasma in freshly diagnosed twenty-five T-2 cases and twelve T-1cases. Thirty normal controls to match the age and sex of the test groups were also studied. The levels of these proteins were correlated with their BMI and random plasma glucose values.

Suggested Citation

  • Shamim Shaikh Mohiuddin & Poornima Manjrekar, 2018. "Comparative Study of Degree of Low Grade Chronic Inflammatory Status in Freshly Diagnosed Type 1 with Type 2 Diabetic Patients," Archives Of Diabetes & Obesity, Lupine Publishers, LLC, vol. 1(5), pages 86-90, November.
  • Handle: RePEc:abr:oajado:v:1:y:2018:i:5:p:86-90
    DOI: 10.32474/ADO.2018.01.000121

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