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Metformin Treatment Represses Vascular Endothelial Growth Factor Gene Transcription in MCF-7 Breast Cancer Cells


  • Mohamed Alalem
  • Bimal K Ray

    (Department of Veterinary Pathobiology, University of Missouri USA
    Genetics Area Program, University of Missouri, USA)


Targeting angiogenesis preferentially in cancer is a promising approach to improve treatment efficacy and safety. The aim of this study is investigate potential upregulation of Krüppel like factor-4(KLF-4) by inhibition of mammalian target of rapamycin (mTOR) to repress vascular endothelial growth factor (VEGF) expression in breast cancer cells.

Suggested Citation

  • Mohamed Alalem & Bimal K Ray, 2018. "Metformin Treatment Represses Vascular Endothelial Growth Factor Gene Transcription in MCF-7 Breast Cancer Cells," Open Access Journal of Oncology and Medicine, Lupine Publishers, LLC, vol. 1(3), pages 61-67, April.
  • Handle: RePEc:abr:joajom:v:1:y:2018:i:3:p:61-67
    DOI: 10.32474/OAJOM.2018.01.000115

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