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Confidence bands for inverse regression models with application to gel electrophoresis

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  • Birke, Melanie
  • Bissantz, Nicolai
  • Holzmann, Hajo
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    Abstract

    We construct uniform confidence bands for the regression function in inverse, homoscedastic regression models with convolution-type operators. Here, the convolution is between two non-periodic functions on the whole real line rather than between two period functions on a compact interval, since the former situation arguably arises more often in applications. First, following Bickel and Rosenblatt [Ann. Statist. 1, 10711095] we construct asymptotic confidence bands which are based on strong approximations and on a limit theorem for the supremum of a stationary Gaussian process. Further, we propose bootstrap confidence bands based on the residual bootstrap. A simulation study shows that the bootstrap confidence bands perform reasonably well for moderate sample sizes. Finally, we apply our method to data from a gel electrophoresis experiment with genetically engineered neuronal receptor subunits incubated with rat brain extract. --

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    Bibliographic Info

    Paper provided by Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen in its series Technical Reports with number 2008,16.

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    Date of creation: 2008
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    Handle: RePEc:zbw:sfb475:200816

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    Keywords: Confidencebands; Inverseproblems; Deconvolution; Rates of convergences; Nonparametric Regression;

    References

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    1. Bissantz, Nicolai & Dümbgen, Lutz & Holzmann, Hajo & Munk, Axel, 2007. "Nonparametric confidence bands in deconvolution density estimation," Technical Reports 2007,03, Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen.
    2. A. Delaigle & I. Gijbels, 2002. "Estimation of integrated squared density derivatives from a contaminated sample," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 64(4), pages 869-886.
    3. Bissantz, Nicolai & Hohage, T. & Munk, Axel & Ruymgaart, F., 2007. "Convergence rates of general regularization methods for statistical inverse problems and applications," Technical Reports 2007,04, Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen.
    4. Härdle, Wolfgang, 1989. "Asymptotic maximal deviation of M-smoothers," Journal of Multivariate Analysis, Elsevier, Elsevier, vol. 29(2), pages 163-179, May.
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    Cited by:
    1. Bissantz, Nicolai & Birke, Melanie, 2008. "Asymptotic normality and confidence intervals for inverse regression models with convolution-type operators," Technical Reports 2008,17, Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen.

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