Christoph Flamm Walter Fontana Ivo L. Hofacker Peter Schuster
Abstract
We study the stochastic folding kinetics of RNA sequences into secondary structures with a new algorithm based on the formation, dissociation, and the shifting of individual base pairs. We discuss folding mechanisms and the correlation between the barrier structure of the conformational landscape and the folding kinetics for a number of examples based on artificial and natural sequences, inculding the influence of base modification in tRNAs.
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Paper provided by Santa Fe Institute in its series Working Papers with number
99-12-078.
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