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Viral RNA and Evolved Mutational Robustness

Author

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  • Andreas Wagner
  • Peter F. Stadler

Abstract

Many properties of organisms show great robustness against mutations. Whether this robustness is an evolved property or intrinsic to genetic systems is by and large unknown. An evolutionary origin of robustness would require a rethinking of key concepts in the field of molecular evolution, such as gene-specific neutral mutation rates, or the context-independence of deleterious mutations. We provide evidence that mutational robustness of the genome of RNA viruses to mutational changes in secondary structure has evolved. Appears in Journal of Experimental Zoology285, pp. 119-127.

Suggested Citation

  • Andreas Wagner & Peter F. Stadler, 1999. "Viral RNA and Evolved Mutational Robustness," Working Papers 99-02-010, Santa Fe Institute.
    • Handle: RePEc:wop:safiwp:99-02-010
    as

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    References listed on IDEAS

    as
    1. Ivo L. Hofacker & Peter F. Stadler, 1998. "Automatic Detection of of Conserved Base Pairing Patterns in RNA Virus Genomes," Working Papers 98-06-058, Santa Fe Institute.
    2. Martin A. Nowak & Maarten C. Boerlijst & Jonathan Cooke & John Maynard Smith, 1997. "Evolution of genetic redundancy," Nature, Nature, vol. 388(6638), pages 167-171, July.
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