The objective of this paper is to compare the cost effectiveness of opportunistic nuchal translucency ultrasound screening in pregnancy with alternative screening strategies for trisomy 21 in Australia. Methods used is a decision analytic model of various pregnancy screening strategies based on a systematic review of the literature on the effectiveness of nuchal translucency ultrasound and serum screening and costs based on current reimbursement fees. The model included the likelihood and cost of terminations following diagnostic testing and the associated risk of fetal loss. All prices are in 2001 Australian dollars.
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