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Costs and Quality of Life in Multiple Sclerosis. A Cross-Sectional Observational Study in the UK

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Author Info

  • Kobelt, Gisela

    (Health Dynamics International Ltd.)

  • Lindgren, Peter

    ()
    (Stockholm Health Economics Consulting AB)

  • Parkin, David

    ()
    (Department of Economics, City University)

  • Francis, David A.

    ()
    (Neurosciences Center, University Hospital Birmingham)

  • Johnson, Michael

    ()
    (Department of Neurology, St Jame´s University Hospital)

  • Bates, David

    ()
    (Department of Neurology, Royal VIctoria Infirmary)

  • Jönsson, Bengt

    ()
    (Dept. of Economics, Stockholm School of Economics)

Abstract

Abstract: We performed a cross-sectional, "bottom-up" observational study of resource consumption and quality of life of patients with multiple sclerosis (MS) in the United Kingdom. Three centers participated in the study. Patients received a questionnaire either by mail or during a clinic visit, and a total of 619 patients returned the questionnaire (the answer rate being around 70%). Patients provided information on all resource consumption, medical and non-medical, work absence and informal care related to their MS. Disease scores (Expanded Disability Status Scale, EDSS) were available for a majority of patients from the study centers, and were assigned using a matrix of disease (mobility) descriptions and EDSS scores. Mean total cost per patient and year was 16’717 £. When this cost is extrapolated to an estimated patient population in the UK of 80’000, total costs to society are estimated at 1.34 billion £. Direct costs represented 28%, informal care accounted for 26% and indirect costs amounted to 46%. Of the direct costs, an estimated £ per patient or % of total costs are paid for by the NHS. Intangible costs were estimated at 5000 £ per patient and year. The mean age of the cohort was 44 years (disease onset 34), the mean utility measured with EQ-5D was 0.487 (0.919 to –0.594), and the mean EDSS score 5.1 (1.0 to 9.5). All costs (direct, informal care, indirect) increased with increasing EDSS scores, while utilities decreased.

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Bibliographic Info

Paper provided by Stockholm School of Economics in its series Working Paper Series in Economics and Finance with number 398.

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Length: 35 pages
Date of creation: 04 Oct 2000
Date of revision:
Handle: RePEc:hhs:hastef:0398

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Postal: The Economic Research Institute, Stockholm School of Economics, P.O. Box 6501, 113 83 Stockholm, Sweden
Phone: +46-(0)8-736 90 00
Fax: +46-(0)8-31 01 57
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Web page: http://www.hhs.se/
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Related research

Keywords: multiple sclerosis; cost-of-illness; quality of life; EDSS; utility;

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Cited by:
  1. Gisela Kobelt & Jenny Berg & Peter Lindgren & Bengt Jönsson, 2006. "Costs and quality of life in multiple sclerosis in Europe: method of assessment and analysis," The European Journal of Health Economics, Springer, vol. 7(2), pages 5-13, July.
  2. Gisela Kobelt & Jenny Berg & Peter Lindgren & W. Elias & P. Flachenecker & M. Freidel & N. König & V. Limmroth & E. Straube, 2006. "Costs and quality of life of multiple sclerosis in Germany," The European Journal of Health Economics, Springer, vol. 7(02), pages 34-44, July.
  3. Gisela Kobelt & Jenny Berg & P. Lindgren & J. Kerrigan & N. Russell & R. Nixon, 2006. "Costs and quality of life of multiple sclerosis in the United Kingdom," The European Journal of Health Economics, Springer, vol. 7(02), pages 96-104, July.
  4. Gisela Kobelt & Jenny Berg & Peter Lindgren & Carlotta Plesnilla & Ulf Baumhackl & Thomas Berger & Harald Kolleger & Karl Vass, 2006. "Costs and quality of life of multiple sclerosis in Austria," The European Journal of Health Economics, Springer, vol. 7(2), pages 14-23, July.
  5. Karl Claxton & Simon Walker & Steven Palmer & Mark Sculpher, 2010. "Appropriate Perspectives for Health Care Decisions," Working Papers 054cherp, Centre for Health Economics, University of York.
  6. Gisela Kobelt & J. Berg & P. Lindgren & G. Izquierdo & O. Sánchez-Soliño & J. Pérez-Miranda & M. Casado, 2006. "Costs and quality of life of multiple sclerosis in Spain," The European Journal of Health Economics, Springer, vol. 7(2), pages 65-74, July.
  7. Kobelt, Gisela & Jönsson, Linus & Fredriksson, Sten & Jönsson, Bengt, 2001. "Cost-utility analysis of Interferon Beta-1b in the treatment of different types of Multiple Sclerosis," Working Paper Series in Economics and Finance 459, Stockholm School of Economics.
  8. Gisela Kobelt & Jenny Berg & P. Lindgren & J. Kerrigan & N. Russell & R. Nixon, 2006. "Costs and quality of life of multiple sclerosis in the United Kingdom," The European Journal of Health Economics, Springer, vol. 7(2), pages 96-104, July.
  9. Jenny Berg & P. Lindgren & Sten Fredrikson & Gisela Kobelt, 2006. "Costs and quality of life of multiple sclerosis in Sweden," The European Journal of Health Economics, Springer, vol. 7(02), pages 75-85, July.
  10. Jenny Berg & P. Lindgren & Sten Fredrikson & Gisela Kobelt, 2006. "Costs and quality of life of multiple sclerosis in Sweden," The European Journal of Health Economics, Springer, vol. 7(2), pages 75-85, July.
  11. Gisela Kobelt, 2006. "Costs and quality of life for patients with multiple sclerosis in Belgium," The European Journal of Health Economics, Springer, vol. 7(2), pages 24-33, July.
  12. Gisela Kobelt & Jenny Berg & Peter Lindgren & W. Elias & P. Flachenecker & M. Freidel & N. König & V. Limmroth & E. Straube, 2006. "Costs and quality of life of multiple sclerosis in Germany," The European Journal of Health Economics, Springer, vol. 7(2), pages 34-44, July.
  13. Gisela Kobelt & Jenny Berg & Peter Lindgren & M. Battaglia & C. Lucioni & A. Uccelli, 2006. "Costs and quality of life of multiple sclerosis in Italy," The European Journal of Health Economics, Springer, vol. 7(2), pages 45-54, July.
  14. Gisela Kobelt, 2006. "Costs and quality of life for patients with multiple sclerosis in Belgium," The European Journal of Health Economics, Springer, vol. 7(02), pages 24-33, July.

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