Advanced Search
MyIDEAS: Login

Adjusted empirical likelihood estimation of the youden index and associated threshold for the bigamia model

Contents:

Author Info

  • Emilio Leton

    ()

  • Elisa M. Molanes
Registered author(s):

    Abstract

    The Youden index is a widely used measure in the framework of medical diagnostic, where the effectiveness of a biomarker (screening marker or predictor) for classifying a disease status is studied. When the biomarker is continuous, it is important to determine the threshold or cut-off point to be used in practice for the discrimination between diseased and healthy populations. We introduce a new method based on adjusted empirical likelihood for quantiles aimed to estimate the Youden index and its associated threshold. We also include bootstrap based confidence intervals for both of them. In the simulation study, we compare this method with a recent approach based on the delta method under the bigamma scenario. Finally, a real example of prostatic cancer, well known in the literature, is analyzed to provide the reader with a better understanding of the new method

    Download Info

    If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
    File URL: http://e-archivo.uc3m.es/bitstream/10016/3816/1/ws091907.pdf
    Download Restriction: no

    Bibliographic Info

    Paper provided by Universidad Carlos III, Departamento de Estadística y Econometría in its series Statistics and Econometrics Working Papers with number ws091907.

    as in new window
    Length:
    Date of creation: Mar 2009
    Date of revision:
    Handle: RePEc:cte:wsrepe:ws091907

    Contact details of provider:
    Postal: C/ Madrid, 126 - 28903 GETAFE (MADRID)
    Phone: 6249847
    Fax: 6249849
    Web page: http://www.uc3m.es/uc3m/dpto/DEE/departamento.html
    More information through EDIRC

    Related research

    Keywords: Confidence interval; Empirical likelihood; Optimal cut-off point; ROC curve; Youden index;

    This paper has been announced in the following NEP Reports:

    References

    No references listed on IDEAS
    You can help add them by filling out this form.

    Citations

    Lists

    This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.

    Statistics

    Access and download statistics

    Corrections

    When requesting a correction, please mention this item's handle: RePEc:cte:wsrepe:ws091907. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: ().

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If references are entirely missing, you can add them using this form.

    If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.