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Is introducing rapid culture in the diagnostic algorithm of smear-negative tuberculosis cost-effective?

Author

Listed:
  • Martine AUDIBERT

    (Centre d'Etudes et de Recherches sur le Développement International(CERDI))

  • Nadia YAKHELEF
  • Marilyne BONNET
  • Jeremiah CHAKAYA
  • Helena HUERGA
  • Joseph SITIENEI
  • Francis VARAINE

Abstract

Setting: In 2007, WHO recommended introducing rapid Mycobacterium tuberculosis (MTB) culture in the diagnostic algorithm of smear-negative pulmonary tuberculosis (TB). Objective: To assess the cost-effectiveness of the introduction of rapid non-commercial culture method (Thin Layer Agar) together with Löwenstein Jensen culture to diagnose smear-negative TB at a district hospital in Kenya. Design: Effectiveness data (number of true TB cases treated) were obtained from a prospective study evaluating the effectiveness of a clinical and radiological algorithm (conventional) with and without (culture-based) MTB culture in 380 smear-negative TB suspects. The costs of each algorithm were calculated using a “micro-costing” or “ingredient-based” method. The cost and effectiveness was compared between conventional and culture-based algorithms and the incremental cost-effectiveness ratio (ICER) was estimated. Results The cost of conventional and culture-based algorithms (per smear-negative TB case) was 15,026€ (39.5€) and 54,931€ (144€), respectively. The cost per TB confirmed and treated case was 455.3€ and 915.5€, respectively. The culture-based algorithm allowed to diagnose and treat 27 more cases for an additional cost of 39,905€ (1478€ per case). Conclusion MTB culture is cost-effective to diagnose smear-negative pulmonary TB according to WHO standards but did not reduce the cost of overtreatment due to long delay of culture results.

Suggested Citation

  • Martine AUDIBERT & Nadia YAKHELEF & Marilyne BONNET & Jeremiah CHAKAYA & Helena HUERGA & Joseph SITIENEI & Francis VARAINE, 2013. "Is introducing rapid culture in the diagnostic algorithm of smear-negative tuberculosis cost-effective?," Working Papers 201317, CERDI.
    • Handle: RePEc:cdi:wpaper:1457
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    References listed on IDEAS

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    1. Drummond, Michael F. & Sculpher, Mark J. & Torrance, George W. & O'Brien, Bernie J. & Stoddart, Greg L., 2005. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 3, number 9780198529453, Decembrie.
    2. Helena Huerga & Francis Varaine & Eric Okwaro & Mathieu Bastard & Elisa Ardizzoni & Joseph Sitienei & Jeremiah Chakaya & Maryline Bonnet, 2012. "Performance of the 2007 WHO Algorithm to Diagnose Smear-Negative Pulmonary Tuberculosis in a HIV Prevalent Setting," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-9, December.
    3. J Lucian Davis & William Worodria & Harriet Kisembo & John Z Metcalfe & Adithya Cattamanchi & Michael Kawooya & Rachel Kyeyune & Saskia den Boon & Krista Powell & Richard Okello & Samuel Yoo & Laurenc, 2010. "Clinical and Radiographic Factors Do Not Accurately Diagnose Smear-Negative Tuberculosis in HIV-infected Inpatients in Uganda: A Cross-Sectional Study," PLOS ONE, Public Library of Science, vol. 5(3), pages 1-8, March.
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    Cited by:

    1. Marilys Victoire Razakamanana & Martine Audibert & Tantely Andrianantoandro & Aina Harimanana, 2017. "Impact and Efficiency of the Integration of Diagnosis and Treatment of Pneumonia in Malaria Community Case Management in Madagascar," Working Papers halshs-01479210, HAL.
    2. Marilys Victoire RAZAKAMANANA & Martine AUDIBERT & Tantely ANDRIANANTOANDRO & Aina HARIMANANA, 2017. "Impact and Efficiency of the Integration of Diagnosis and Treatment of Pneumonia in Malaria Community Case Management in Madagascar," Working Papers 201706, CERDI.

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