IDEAS home Printed from https://ideas.repec.org/p/bep/ucbbio/1148.html
   My bibliography  Save this paper

Mean Response Models of Repeated Measurements in Presence of Varying Effectiveness Onset

Author

Listed:
  • Ying Chen

    (Division of Biostatistics, School of Public Health, University of California, Berkeley)

  • Su-Chun Cheng

    (Department of Epidemiology & Biostatistics, University of California, San Francisco)

Abstract

Repeated measurements are often collected over time to evaluate treatment efficacy in clinical trials. Most of the statistical models of the repeated measurements have been focusing on their mean response as function of time. These models usually assume that the treatment has persistent effect of constant additivity or multiplicity on the mean response functions throughout the observation period of time. In reality, however, such assumption may be confounded by the potential existence of the so-called effectiveness action onset, although they are often unobserved or difficult to obtain. Instead of including nonparametric time-varying coefficients in the mean response models, we propose and study some semiparametric mean response models to accommodate such effectiveness times. Our methodologies will be demonstrated by a real randomised clinical trial data.

Suggested Citation

  • Ying Chen & Su-Chun Cheng, 2004. "Mean Response Models of Repeated Measurements in Presence of Varying Effectiveness Onset," U.C. Berkeley Division of Biostatistics Working Paper Series 1148, Berkeley Electronic Press.
    • Handle: RePEc:bep:ucbbio:1148
    Note: oai:bepress.com:ucbbiostat-1148
    as

    Download full text from publisher

    File URL: http://www.bepress.com/cgi/viewcontent.cgi?article=1148&context=ucbbiostat
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Chiang C-T. & Rice J. A & Wu C. O, 2001. "Smoothing Spline Estimation for Varying Coefficient Models With Repeatedly Measured Dependent Variables," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 605-619, June.
    2. Y. Q. Chen, 2002. "Additive hazards models with latent treatment effectiveness lag time," Biometrika, Biometrika Trust, vol. 89(4), pages 917-931, December.
    3. Yatchew, A., 1997. "An elementary estimator of the partial linear model," Economics Letters, Elsevier, vol. 57(2), pages 135-143, December.
    4. J. Sun & L. J. Wei, 2000. "Regression analysis of panel count data with covariate‐dependent observation and censoring times," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 62(2), pages 293-302.
    5. Lin D Y & Ying Z, 2001. "Semiparametric and Nonparametric Regression Analysis of Longitudinal Data," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 103-126, March.
    6. Jianhua Z. Huang, 2002. "Varying-coefficient models and basis function approximations for the analysis of repeated measurements," Biometrika, Biometrika Trust, vol. 89(1), pages 111-128, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ye, Mao & Lu, Zhao-Hua & Li, Yimei & Song, Xinyuan, 2019. "Finite mixture of varying coefficient model: Estimation and component selection," Journal of Multivariate Analysis, Elsevier, vol. 171(C), pages 452-474.
    2. Wang, Qihua & Zhang, Riquan, 2009. "Statistical estimation in varying coefficient models with surrogate data and validation sampling," Journal of Multivariate Analysis, Elsevier, vol. 100(10), pages 2389-2405, November.
    3. Olga Klopp & Marianna Pensky, 2013. "Sparse High-dimensional Varying Coefficient Model : Non-asymptotic Minimax Study," Working Papers 2013-30, Center for Research in Economics and Statistics.
    4. Tang Qingguo & Cheng Longsheng, 2008. "M-estimation and B-spline approximation for varying coefficient models with longitudinal data," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 20(7), pages 611-625.
    5. Qiu, Jia & Li, Degao & You, Jinhong, 2015. "SCAD-penalized regression for varying-coefficient models with autoregressive errors," Journal of Multivariate Analysis, Elsevier, vol. 137(C), pages 100-118.
    6. Chen, Xuerong & Tang, Niansheng & Zhou, Yong, 2016. "Quantile regression of longitudinal data with informative observation times," Journal of Multivariate Analysis, Elsevier, vol. 144(C), pages 176-188.
    7. Wang-Li Xu & Li-Xing Zhu, 2008. "Goodness-of-fit testing for varying-coefficient models," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 68(2), pages 129-146, September.
    8. Yiqiang Lu & Riquan Zhang, 2009. "Smoothing spline estimation of generalised varying-coefficient mixed model," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 21(7), pages 815-825.
    9. Liu, Hefei & Song, Xinyuan & Zhang, Baoxue, 2022. "Varying-coefficient hidden Markov models with zero-effect regions," Computational Statistics & Data Analysis, Elsevier, vol. 173(C).
    10. Jun Jin & Tiefeng Ma & Jiajia Dai, 2021. "New efficient spline estimation for varying-coefficient models with two-step knot number selection," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 84(5), pages 693-712, July.
    11. Rahul Ghosal & Arnab Maity & Timothy Clark & Stefano B. Longo, 2020. "Variable selection in functional linear concurrent regression," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 69(3), pages 565-587, June.
    12. Chin-Tsang Chiang, 2005. "Comparisons between simultaneous and componentwise splines for varying coefficient models," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 57(4), pages 637-653, December.
    13. Weihua Zhao & Weiping Zhang & Heng Lian, 2020. "Marginal quantile regression for varying coefficient models with longitudinal data," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 72(1), pages 213-234, February.
    14. Long Feng & Changliang Zou & Zhaojun Wang & Xianwu Wei & Bin Chen, 2015. "Robust spline-based variable selection in varying coefficient model," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 78(1), pages 85-118, January.
    15. Peixin Zhao & Liugen Xue, 2011. "Variable selection for varying coefficient models with measurement errors," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 74(2), pages 231-245, September.
    16. Kong, Dehan & Bondell, Howard D. & Wu, Yichao, 2015. "Domain selection for the varying coefficient model via local polynomial regression," Computational Statistics & Data Analysis, Elsevier, vol. 83(C), pages 236-250.
    17. Zhaoping Hong & Yuao Hu & Heng Lian, 2013. "Variable selection for high-dimensional varying coefficient partially linear models via nonconcave penalty," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 76(7), pages 887-908, October.
    18. Wang-Li Xu & Li-Xing Zhu, 2009. "A goodness-of-fit test for a varying-coefficients model in longitudinal studies," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 21(4), pages 427-440.
    19. Stremersch, S. & Lemmens, A., 2008. "Sales Growth of New Pharmaceuticals Across the Globe: The Role of Regulatory Regimes," ERIM Report Series Research in Management ERS-2008-026-MKT, Erasmus Research Institute of Management (ERIM), ERIM is the joint research institute of the Rotterdam School of Management, Erasmus University and the Erasmus School of Economics (ESE) at Erasmus University Rotterdam.
    20. Linjun Tang & Zhangong Zhou, 2015. "Weighted local linear CQR for varying-coefficient models with missing covariates," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 24(3), pages 583-604, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bep:ucbbio:1148. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Christopher F. Baum (email available below). General contact details of provider: http://www.bepress.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.