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Economic and Humanistic Burden of External Genital Warts

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Author Info

  • Adam J.N. Raymakers

    (Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada)

  • Mohsen Sadatsafavi

    (Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada)

  • Fawziah Marra

    (Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada; Vaccine and Pharmacy Services, BC Centre for Disease Control, Vancouver, BC, Canada)

  • Carlo A. Marra

    (Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada; Centre for Health Evaluation and Outcomes Sciences, Providence Health Care Research Institute, Vancouver, BC, Canada)

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    Abstract

    External genital warts (EGW) are a sexually transmitted infection caused by various strains of human papillomavirus (HPV). Several studies have described the direct and indirect costs of EGW, while others have reported on the burden of EGW in terms of the impact on the quality of life (QOL) of patients. The arrival of a quadrivalent HPV vaccine that protects against both cervical cancer and EGW requires a proper understanding of the impact of vaccines on costs and QOL. Using pre-defined search terms and inclusion/exclusion criteria, we performed a systematic review of the economic and humanistic burden of EGW. The focus of our review was on literature describing the direct and indirect costs of EGW per episode of care (EoC) or per year, as well as the impact of EGW on disease-specific, generic, or preference-based QOL measures. We also reviewed the literature on the national economic burden of EGW from the perspectives of different countries. Other aspects of EGW management that can inform economic modelling studies, such as length of EoC, number of physician visits and indirect costs, were also explored. Our review sheds light on the high economic and humanistic burden of EGW and important differences in the costs between men and women, as well as the differences in health resource utilization and costs across countries. Our study also highlights the dearth of information on the impact of EGW on the QOL and productivity of patients.

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    Bibliographic Info

    Article provided by Springer Healthcare | Adis in its journal PharmacoEconomics.

    Volume (Year): 30 (2012)
    Issue (Month): 1 ()
    Pages: 1-16

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    Handle: RePEc:wkh:phecon:v:30:y:2012:i:1:p:1-16

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    Web page: http://pharmacoeconomics.adisonline.com/

    Related research

    Keywords: Cost-of-illness; Genital-warts; Human-papillomavirus-infections; Human-papillomavirus-vaccine; Quality-of-life.;

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