Measuring the Externality of Antibacterial Use from Promoting Antimicrobial Resistance
AbstractBackground: The emergence and spread of antimicrobial resistance (AMR) has become a serious public health threat. Rational antibacterial policy, combined with enforcement of infection control practices are key strategies to combat AMR in the hospital setting. Loss of antibacterial activity as a direct result of antibacterial consumption can be modelled via the economic approach of a negative externality. Objective: To determine the externalities of antibacterial consumption and alcohol-based hand rub use for hand disinfection. Methods: A simple model was built, combining the results of a recently conducted cost-of-illness study with the results of a multivariate time-series analysis, which determined the impact of antibacterial consumption and alcohol-based hand rub use on the incidence of hospital-acquired infections caused by meticillin-resistant Staphylococcus aureus (MRSA). Results: Consumption of a single defined daily dose of second-generation cephalosporins, third-generation cephalosporins, fluoroquinolones and lincosamides is associated with a negative externality of about &U20AC;5, &U20AC;15, &U20AC;11 and &U20AC;12, respectively. In contrast, use of 1 litre of alcohol-based hand rub solution for hand disinfection is associated with a positive externality of about &U20AC;61. In other words, a single disinfection of the hands (use of 3 mL alcohol-based hand rub solution) saves an average &U20AC;0.18 of the potential cost incurred by MRSA-related infections. Conclusions: Quantifying the externalities of antibacterial use and alcohol-based hand rub use may lead to changes in prescribing behaviour and increase compliance with hand disinfection. Furthermore, the presented methodology of relating the cost of resistance to specific factors such as antibacterial use and hand disinfection provides information that may be useful for prioritizing prevention methods.
Download InfoIf you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
Bibliographic InfoArticle provided by Springer Healthcare | Adis in its journal PharmacoEconomics.
Volume (Year): 28 (2010)
Issue (Month): 12 ()
Contact details of provider:
Web page: http://pharmacoeconomics.adisonline.com/
Antimicrobial-resistance; Cephalosporins; therapeutic use; Cost-analysis; Fluoroquinolones; therapeutic use; Lincosamides; therapeutic use; Methicillin-resistant-Staphylococcus-aureus-infections; Prevention.;
Find related papers by JEL classification:
- C - Mathematical and Quantitative Methods
- D - Microeconomics
- I - Health, Education, and Welfare
- Z - Other Special Topics
- I1 - Health, Education, and Welfare - - Health
- I19 - Health, Education, and Welfare - - Health - - - Other
- I18 - Health, Education, and Welfare - - Health - - - Government Policy; Regulation; Public Health
- I11 - Health, Education, and Welfare - - Health - - - Analysis of Health Care Markets
You can help add them by filling out this form.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Dave Dustin).
If references are entirely missing, you can add them using this form.