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Dynamic Modelling of Infectious Diseases: An Application to the Economic Evaluation of Influenza Vaccination

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Author Info

  • Roberto Pradas-Velasco

    (Centro Sagrado Corazon, Logrono, Spain, Universidad de la Rioja, Logrono, Spain)

  • Fernando Antonanzas-Villar

    (Universidad de la Rioja, Logrono, Spain)

  • Maria Puy Martinez-Zarate

    (Consejeria de Salud del Gobierno de la Rioja, Logrono, Spain)

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    Abstract

    Objective: To evaluate the economic efficiency of influenza vaccination using both dynamic and static modelling approaches. Setting: The Spanish National Health System. Design and methods: We modelled the progress of an influenza epidemic in Spain according to the epidemiological pattern of susceptible->infective->resistant, employing a non-linear system of ordinary differential equations that enables the measurement of epidemiological effects of an anti-influenza vaccination. We used a decision tree to represent the repercussion on healthcare resources use and on financial resources. The same analyses were conducted using a static approach, and the results were compared. Healthcare costs were valued in _, year 2005 values. Results: For the base case, the impact of the healthcare intervention (vaccination) was not efficient from the perspective of the healthcare payer when using a static approach (return rate 0.28 per _ invested in vaccination). Nevertheless, it was efficient when employing a dynamic approach (return rate 1.22 per _). Furthermore, a considerable freeing of healthcare resources would have been produced over the entire influenza season. Conclusions: The indirect effect of vaccination on the non-vaccinated individuals (the `herd immunity effect') can be greater than the direct effect on individuals vaccinated. This implies that the herd immunity effect needs to be taken into consideration in the economic evaluations of prophylactic measures employed against infectious diseases.

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    Bibliographic Info

    Article provided by Springer Healthcare | Adis in its journal PharmacoEconomics.

    Volume (Year): 26 (2008)
    Issue (Month): 1 ()
    Pages: 45-56
    Download reference. The following formats are available: HTML (with abstract), plain text (with abstract), BibTeX, RIS (EndNote, RefMan, ProCite), ReDIF
    Handle: RePEc:wkh:phecon:v:26:y:2008:i:1:p:45-56

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    Web page: http://pharmacoeconomics.adisonline.com/

    For corrections or technical questions regarding this item, or to correct its listing, contact: (Dave Dustin).

    Related research

    Keywords: Cost-analysis; Influenza-virus-infections; Influenza-virus-vaccine; Modelling;

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