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Economic Evaluation of Antibacterials in the Treatment of Acute Sinusitis

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Author Info

  • Claudine Laurier

    (Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada)

  • Jean Lachaine

    (Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada)

  • Murray Ducharme

    (Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada)

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    Abstract

    Objective: The objective of this study was to compare costs, efficacy and cost efficacy of alternate oral antibacterial regimens for the ambulatory treatment of acute sinusitis. A public third-party perspective was adopted. Design: The analysis was based on a decision tree and considered the episode of care from the decision to initiate an antibacterial until the end of the first course of treatment or the end of a subsequent course of treatment when needed. Efficacy data were retrieved from published clinical trials. Direct medical costs included the costs of physician visits, diagnostic tests and medications. Setting: The study pertained to adults treated in a primary-care setting in the Canadian province of Quebec. Interventions: The antibacterials studied were amoxicillin, amoxicillin/clavulanate, azithromycin, cefaclor, cefuroxime axetil and clarithromycin. Main outcome measures and results: The main outcome measured was the proportion of patients showing resolution or improvement of their symptoms. Initiating a treatment with amoxicillin was associated with similar efficacy and lower overall costs when compared with the other antibacterials. Low dosages of clarithromycin and azithromycin followed amoxicillin in terms of cost-efficacy ratio. Conclusions: This study confirms the place of amoxicillin as a first choice agent for acute sinusitis, with low dose clarithromycin and azithromycin as second choices.

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    Bibliographic Info

    Article provided by Springer Healthcare | Adis in its journal PharmacoEconomics.

    Volume (Year): 15 (1999)
    Issue (Month): 1 ()
    Pages: 97-113
    Download reference. The following formats are available: HTML (with abstract), plain text (with abstract), BibTeX, RIS (EndNote, RefMan, ProCite), ReDIF
    Handle: RePEc:wkh:phecon:v:15:y:1999:i:1:p:97-113

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    Web page: http://pharmacoeconomics.adisonline.com/

    For corrections or technical questions regarding this item, or to correct its listing, contact: (Dave Dustin).

    Related research

    Keywords: Pharmacoeconomics; Sinusitis; Cost-analysis; Amoxicillin; Amoxicillin.clavulanic-acid; Azithromycin; Cefaclor; Cefuroxime-axetil; Clarithromycin; Antibacterials;

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