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Clinical and Economic Comparison of Sertraline and Fluoxetine in the Treatment of Depression: A 6-Month Double-Blind Study in a Primary-Care Setting in France

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Author Info

  • P. Boyer

    (URA 1957 CNRS Hopital La Salpetriere, Paris, France)

  • J.M. Danion

    (Unite INSERM U405 Hopitaux Universitaires de Strasbourg, Strasbourg, France)

  • J.C. Bisserbe

    (24 chemin des Lacets, Meudon, France)

  • J.M. Hotton

    (Pfizer France, Orsay, France)

  • S. Troy

    (Pfizer France, Orsay, France)

Registered author(s):

    Abstract

    In a double-blind study in a primary-care setting in France, outpatients fulfilling DSM IV criteria for a major depressive episode were randomised to receive sertraline (50 to 150 mg/day; n = 122) or fluoxetine (20 to 60 mg/day; n = 120). Assessments, including clinical evaluation [Montgomery-Asberg Depression Rating Scale (MADRS), Clinical Global Impressions (CGI)] and quality of life [Functional Status Questionnaire (FSQ)], were made at study entry and after 4 and 6 months of treatment. Use of medical services, absences from work and productivity losses were recorded for calculation of direct and indirect costs from both the overall societal perspective and in terms of sickness insurance. In total, 231 patients (116 receiving sertraline, 115 receiving fluoxetine) were included in an intention-to-treat analysis assessed up to the last visit. Statistically significant clinical and quality-of-life improvements from baseline were observed in both treatment groups, with no between-group differences. Utilisation of medical resources was higher in fluoxetine-treated patients, with significantly more consultations with specialists. The 2 treatment groups were similar in terms of number of hospitalisations and duration of stay, whether related to depression or not. There were no significant differences between groups for work or productivity losses. Cost comparisons favoured sertraline treatment from both the societal (FF7780 vs FF8706) and sickness insurance (FF2936 vs FF3224) viewpoints, with cost differentials of FF926 and FF288, respectively. From the societal perspective, the total cost per patient over the 6-month course of the trial, irrespective of the study treatment given, was FF8241, and the corresponding sickness insurance cost was FF3079. At the time of the study, FF1 = $US0.1993.

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    Bibliographic Info

    Article provided by Springer Healthcare | Adis in its journal PharmacoEconomics.

    Volume (Year): 13 (1998)
    Issue (Month): 1 Part 2 ()
    Pages: 157-169
    Download reference. The following formats are available: HTML (with abstract), plain text (with abstract), BibTeX, RIS (EndNote, RefMan, ProCite), ReDIF
    Handle: RePEc:wkh:phecon:v:13:y:1998:i:1-part-2:p:157-169

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    Web page: http://pharmacoeconomics.adisonline.com/

    For corrections or technical questions regarding this item, or to correct its listing, contact: (Dave Dustin).

    Related research

    Keywords: Pharmacoeconomics; Depression; Sertraline; Fluoxetine; Cost-analysis; Quality-of-life; Randomised-controlled-trials; Serotonin-uptake-inhibitors;

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