Advanced Search

The Economics of Hepatitis B Virus Vaccination: An Analysis of Cost-Effectiveness Results for Switzerland

Contents:

Author Info

  • Pascal Zurn

    (University of Lausanne, Lausanne, Switzerland)

  • Guy Carrin

    (World Health Organization, Geneva, Switzerland)

  • Jean-Pierre Danthine

    (University of Lausanne, Lausanne, Switzerland)

  • Raoul Kammerlander

    (Swiss Federal Office of Public Health, Bern, Switzerland)

  • Mark Kane

    (World Health Organization, Geneva, Switzerland)

Abstract

Objective: To assess and compare the costs and effectiveness of different vaccination strategies against hepatitis B in Switzerland. Design: A birth cohort of 85 000 individuals was followed over their lifetime, using a decision-tree analysis. Published data were used to simulate the risk of hepatitis B virus (HBV) infection in the cohort, the consecutive clinical outcomes and the associated costs. Five new vaccination scenarios were assessed and compared with a baseline strategy of vaccination of high-risk groups. The 5 new vaccination scenarios were: (i) systematic prenatal screening and vaccination of newborns at risk; (ii) universal vaccination of infants; (iii) universal vaccination of school children; (iv) universal vaccination of infants and school children; and (v) universal vaccination of infants, school children and adolescents. Results: The incremental cost per year of life saved for systematic prenatal screening and vaccination of newborns at risk compared with the baseline scenario was estimated to be 23 350 Swiss francs (SwF; 1996 values). The 4 universal vaccination scenarios had a much larger impact on the number of chronic infections and deaths prevented. The incremental cost per year of life saved for universal vaccination compared with systematic prenatal screening and vaccination of newborns at risk ranged from SwF6120 (infant vaccination strategy) to SwF10 200 (school children vaccination strategy). In the sensitivity analysis, prevalence, vaccine price and discount rate were key elements. Conclusion: Incremental cost-effectiveness ratios are lower with universal vaccination strategies than with selective vaccination. Furthermore, with universal vaccination strategies, increasingly ambitious strategies result in higher costs but also in more incremental years of life saved.

Download Info

If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
File URL: http://diseasemanagement.adisonline.com/pt/re/dmo/pdfhandler.00115677-200007060-00004.pdf
Download Restriction: Pay per view
File URL: http://diseasemanagement.adisonline.com/pt/re/dmo/fulltext.00115677-200007060-00004.htm
Download Restriction: Pay per view

As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.

Bibliographic Info

Article provided by Wolters Kluwer Health | Adis in its journal Disease Management & Health Outcomes.

Volume (Year): 7 (2000)
Issue (Month): 6 ()
Pages: 331-347
Download reference. The following formats are available: HTML (with abstract), plain text (with abstract), BibTeX, RIS (EndNote, RefMan, ProCite), ReDIF
Handle: RePEc:wkh:dmhout:v:7:y:2000:i:6:p:331-347

Contact details of provider:
Web page: http://diseasemanagement.adisonline.com/

For corrections or technical questions regarding this item, or to correct its listing, contact: (Dave Dustin).

Related research

Keywords: Adolescents; Children; Cost effectiveness; Hepatitis B; Hepatitis B vaccine; Infants; Neonates; Pharmacoeconomics; Vaccines;

Find related papers by JEL classification:

References

No references listed on IDEAS
You can help add them by filling out this form.

Citations

Lists

This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.

Statistics

Access and download statistics

Corrections

When requesting a correction, please mention this item's handle: RePEc:wkh:dmhout:v:7:y:2000:i:6:p:331-347

For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Dave Dustin).

If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

If references are entirely missing, you can add them using this form.

If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

Please note that corrections may take a couple of weeks to filter through the various RePEc services.