Advanced Search
MyIDEAS: Login to save this article or follow this journal

Immune Response and Imperfect Vaccine in Malaria Dynamics

Contents:

Author Info

  • ASHRAFI NIGER
  • ABBA GUMEL
Registered author(s):

    Abstract

    The immune response to malaria and the effects of an imperfect vaccine for this disease are modelled incorporating an n stage parasite life cycle, immune cells, and antibodies. A globally asymptotically stable parasite-free equilibrium occurs when the associated reproduction number is less than unity. An imperfect malaria vaccine that reduces the number of merozoites released per bursting infected red blood cell (IRBC) and that boosts immune response can reduce the concentration of IRBCs in vivo. Numerical simulations show that a vaccine efficacy of at least 87% is necessary to eliminate IRBC in vivo. The concentration of IRBCs varies with the capacity of the vaccine to modify the total number of merozoites released per bursting IRBC.

    Download Info

    If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
    File URL: http://www.tandfonline.com/doi/abs/10.1080/08898480.2011.564560
    Download Restriction: Access to full text is restricted to subscribers.

    As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.

    Bibliographic Info

    Article provided by Taylor & Francis Journals in its journal Mathematical Population Studies.

    Volume (Year): 18 (2011)
    Issue (Month): 2 ()
    Pages: 55-86

    as in new window
    Handle: RePEc:taf:mpopst:v:18:y:2011:i:2:p:55-86

    Contact details of provider:
    Web page: http://www.tandfonline.com/GMPS20

    Order Information:
    Web: http://www.tandfonline.com/pricing/journal/GMPS20

    Related research

    Keywords: immune response; malaria; ordinary differential equations; vaccine;

    References

    No references listed on IDEAS
    You can help add them by filling out this form.

    Citations

    Lists

    This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.

    Statistics

    Access and download statistics

    Corrections

    When requesting a correction, please mention this item's handle: RePEc:taf:mpopst:v:18:y:2011:i:2:p:55-86. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Michael McNulty).

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If references are entirely missing, you can add them using this form.

    If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.