Advanced Search
MyIDEAS: Login to save this article or follow this journal

When a Collective Outcome Triggers a Rare Individual Event: A Mode of Metastatic Process in a Cell Population

Contents:

Author Info

  • MICHEL MALO
  • AMANDINE CARTIER-MICHAUD
  • ELISABETH FABRE-GUILLEVIN
  • GUILLAUME HUTZLER
  • FRANCK DELAPLACE
  • GEORGIA BARLOVATZ-MEIMON
  • ANNICK LESNE
Registered author(s):

    Abstract

    A model of early metastatic process is based on the role of the protein PAI-1, which at high enough extracellular concentration promotes the transition of cancer cells to a state prone to migration. This transition is described at the single cell level as a bi-stable switch associated with a subcritical bifurcation. In a multilevel reaction-diffusion scenario, the micro-environment of the tumor is modified by the proliferating cell population so as to push the concentration of PAI-1 above the bifurcation threshold. The formulation in terms of partial differential equations fails to capture spatio-temporal heterogeneity. Cellular-automata and agent-based simulations of cell populations support the hypothesis that a randomly localized accumulation of PAI-1 can arise and trigger the escape of a few isolated cells. Far away from the primary tumor, these cells experience a reverse transition back to a proliferative state and could generate a secondary tumor. The suggested role of PAI-1 in controlling this metastatic cycle is candidate to explain its role in the progression of cancer.

    Download Info

    If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
    File URL: http://www.tandfonline.com/doi/abs/10.1080/08898480.2010.490996
    Download Restriction: Access to full text is restricted to subscribers.

    As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.

    Bibliographic Info

    Article provided by Taylor & Francis Journals in its journal Mathematical Population Studies.

    Volume (Year): 17 (2010)
    Issue (Month): 3 ()
    Pages: 136-165

    as in new window
    Handle: RePEc:taf:mpopst:v:17:y:2010:i:3:p:136-165

    Contact details of provider:
    Web page: http://www.tandfonline.com/GMPS20

    Order Information:
    Web: http://www.tandfonline.com/pricing/journal/GMPS20

    Related research

    Keywords: agent-based simulation; cell population; metastastic escape; multilevel model; multistability; reaction-diffusion;

    References

    No references listed on IDEAS
    You can help add them by filling out this form.

    Citations

    Lists

    This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.

    Statistics

    Access and download statistics

    Corrections

    When requesting a correction, please mention this item's handle: RePEc:taf:mpopst:v:17:y:2010:i:3:p:136-165. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Michael McNulty).

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If references are entirely missing, you can add them using this form.

    If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.