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The Impact of Structural Uncertainty on Cost-Effectiveness Models for Adjuvant Endocrine Breast Cancer Treatments: the Need for Disease-Specific Model Standardization and Improved Guidance

Author

Listed:
  • Gerardus Frederix
  • Johan Hasselt
  • Jan Schellens
  • Anke Hövels
  • Jan Raaijmakers
  • Alwin Huitema
  • Johan Severens

Abstract

Differences in model structure and parameterization lead to substantial differences in analysis outcome metrics. This analysis supports the need for more guidance regarding structural uncertainty and the use of standardized disease-specific models for health economic analyses of adjuvant endocrine breast cancer therapies. The developed approach in the current analysis could potentially serve as a template for further evaluations of structural uncertainty and development of disease-specific models. Copyright Springer International Publishing Switzerland 2014

Suggested Citation

  • Gerardus Frederix & Johan Hasselt & Jan Schellens & Anke Hövels & Jan Raaijmakers & Alwin Huitema & Johan Severens, 2014. "The Impact of Structural Uncertainty on Cost-Effectiveness Models for Adjuvant Endocrine Breast Cancer Treatments: the Need for Disease-Specific Model Standardization and Improved Guidance," PharmacoEconomics, Springer, vol. 32(1), pages 47-61, January.
    • Handle: RePEc:spr:pharme:v:32:y:2014:i:1:p:47-61
    DOI: 10.1007/s40273-013-0106-x
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    Cited by:

    1. Hossein Haji Ali Afzali & Jonathan Karnon & Olga Theou & Justin Beilby & Matteo Cesari & Renuka Visvanathan, 2019. "Structuring a conceptual model for cost-effectiveness analysis of frailty interventions," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-13, September.
    2. Clare Proudfoot & Raju Gautam & Joaquim Cristino & Rumjhum Agrawal & Lalit Thakur & Keith Tolley, 2023. "Model parameters influencing the cost-effectiveness of sacubitril/valsartan in heart failure: evidence from a systematic literature review," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 24(3), pages 453-467, April.
    3. T I Armina Padmasawitri & Gerardus W Frederix & Bachti Alisjahbana & Olaf Klungel & Anke M Hövels, 2018. "Disparities in model-based cost-effectiveness analyses of tuberculosis diagnosis: A systematic review," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-20, May.
    4. Hester V Eeren & Saskia J Schawo & Ron H J Scholte & Jan J V Busschbach & Leona Hakkaart, 2015. "Value of Information Analysis Applied to the Economic Evaluation of Interventions Aimed at Reducing Juvenile Delinquency: An Illustration," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-15, July.

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