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Protein model exhibiting three folding transitions

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  • Bakk, Audun
  • Hansen, Alex
  • Sneppen, Kim

Abstract

We explain the physical basis of a very simple hierarchical model for small globular proteins with water interactions. The water is supposed to accesses the protein interior in an “all-or-none” manner during the unfolding of the protein chain. As a consequence of this mechanism (somewhat speculative), the model exhibits fundamental aspects of protein thermodynamics, as cold and warm unfolding of the polypeptide chain. Decreasing the temperature below the cold unfolding the protein folds again. Accordingly, the heat capacity has three characteristic peaks. The cold and warm unfolding has a sharpness close to a two-state system, while the cold folding yields a less sharp transition. Interestingly, the entropy of the protein chain drives both the cold folding and the warm unfolding.

Suggested Citation

  • Bakk, Audun & Hansen, Alex & Sneppen, Kim, 2001. "Protein model exhibiting three folding transitions," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 291(1), pages 60-70.
    • Handle: RePEc:eee:phsmap:v:291:y:2001:i:1:p:60-70
    DOI: 10.1016/S0378-4371(00)00611-7
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    References listed on IDEAS

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    1. Hansen, Alex & Jensen, Mogens H & Sneppen, Kim & Zocchi, Giovanni, 1999. "A model for the thermodynamics of globular proteins," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 270(1), pages 278-287.
    2. Hansen, Alex & Jensen, Mogens H. & Sneppen, Kim & Zocchi, Giovanni, 1998. "A hierarchical scheme for cooperativity and folding in proteins," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 250(1), pages 355-361.
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    Cited by:

    1. Bakk, Audun & Høye, Johan S. & Hansen, Alex, 2002. "Specific heat upon aqueous unfolding of the protein interior: a theoretical approach," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 304(3), pages 355-361.
    2. Bakk, Audun & Høye, Johan S., 2003. "One-dimensional Ising model applied to protein folding," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 323(C), pages 504-518.

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    1. Bakk, Audun & Høye, Johan S. & Hansen, Alex, 2002. "Specific heat upon aqueous unfolding of the protein interior: a theoretical approach," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 304(3), pages 355-361.

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