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Robust and irreversible development in cell society as a general consequence of intra–inter dynamics

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  • Kaneko, Kunihiko
  • Furusawa, Chikara

Abstract

A dynamical systems scenario for developmental cell biology is proposed, based on numerical studies of a system with interacting units with internal dynamics and reproduction. Diversification, formation of discrete and recursive types, and rules for differentiation are found as a natural consequence of such a system. “Stem cells” that either proliferate or differentiate to different types stochastically are found to appear when intra-cellular dynamics are chaotic. Robustness of the developmental process against microscopic and macroscopic perturbations is shown to be a natural consequence of such intra–inter dynamics, while irreversibility in developmental process is discussed in terms of the gain of stability, loss of diversity and chaotic instability.

Suggested Citation

  • Kaneko, Kunihiko & Furusawa, Chikara, 2000. "Robust and irreversible development in cell society as a general consequence of intra–inter dynamics," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 280(1), pages 22-33.
    • Handle: RePEc:eee:phsmap:v:280:y:2000:i:1:p:22-33
    DOI: 10.1016/S0378-4371(99)00615-9
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