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The dimension dependence of gel electrophoresis

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  • Leegwater, Jan A.

Abstract

We study the significance of self-avoidance on the dynamics of a reptating polymer in a field. We show that in two dimensions the drift velocity decreases with field above a certain field strength due to self-trapping of the polymer. This phenomenon does not occur in more than two dimensions. We conclude that there is a crucial difference between electrophoresis in two and electrophoresis in more than two dimensions and that electrophoresis in a plane has the potential for a much better size-selectivity than gel electrophoresis in three dimensions. Moreover, we establish a scaling law for the drift velocity of a two-dimensional polymer, and show that the scaling variable is N2.5±0.03ε.

Suggested Citation

  • Leegwater, Jan A., 1998. "The dimension dependence of gel electrophoresis," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 251(1), pages 202-210.
    • Handle: RePEc:eee:phsmap:v:251:y:1998:i:1:p:202-210
    DOI: 10.1016/S0378-4371(97)00604-3
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