Steady-state optimization of biochemical systems through geometric programming
AbstractThis paper presents an iterative strategy to address the steady-state optimization of biochemical systems. In the method we take advantage of a special class of nonlinear kinetic models known as Generalized Mass Action (GMA) models. These systems are interesting in that they allow direct merging of stoichiometric and S-system models. In most cases nonconvex steady-state optimization problems with GMA models cannot be transformed into tractable convex formulations, but an iterative strategy can be used to compute the optimal solution by solving a series of geometric programming. The presented framework is applied to several case studies and shown to the tractability and effectiveness of the method. The simulation is also studied to investigate the convergence properties of the algorithm and to give a performance comparison of our proposed and other approaches.
Download InfoIf you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
Bibliographic InfoArticle provided by Elsevier in its journal European Journal of Operational Research.
Volume (Year): 225 (2013)
Issue (Month): 1 ()
Contact details of provider:
Web page: http://www.elsevier.com/locate/eor
OR in biology; Optimization; Geometric programming; Generalized mass action; Biochemical systems;
You can help add them by filling out this form.
CitEc Project, subscribe to its RSS feed for this item.
- Xu, Gongxian, 2014. "Global optimization of signomial geometric programming problems," European Journal of Operational Research, Elsevier, vol. 233(3), pages 500-510.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Zhang, Lei).
If references are entirely missing, you can add them using this form.