Advanced Search
MyIDEAS: Login to save this article or follow this journal

A two-phase method for selecting IMRT treatment beam angles: Branch-and-Prune and local neighborhood search


Author Info

  • Lim, Gino J.
  • Cao, Wenhua
Registered author(s):


    This paper presents a new two-phase solution approach to the beam angle and fluence map optimization problem in Intensity Modulated Radiation Therapy (IMRT) planning. We introduce Branch-and-Prune (B&P) to generate a robust feasible solution in the first phase. A local neighborhood search algorithm is developed to find a local optimal solution from the Phase I starting point in the second phase. The goal of the first phase is to generate a clinically acceptable feasible solution in a fast manner based on a Branch-and-Bound tree. In this approach, a substantially reduced search tree is iteratively constructed. In each iteration, a merit score based branching rule is used to select a pool of promising child nodes. Then pruning rules are applied to select one child node as the branching node for the next iteration. The algorithm terminates when we obtain a desired number of angles in the current node. Although Phase I generates quality feasible solutions, it does not guarantee optimality. Therefore, the second phase is designed to converge Phase I starting solutions to local optimality. Our methods are tested on two sets of real patient data. Results show that not only can B&P alone generate clinically acceptable solutions, but the two-phase method consistently generates local optimal solutions, some of which are shown to be globally optimal.

    Download Info

    If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
    File URL:
    Download Restriction: Full text for ScienceDirect subscribers only

    As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.

    Bibliographic Info

    Article provided by Elsevier in its journal European Journal of Operational Research.

    Volume (Year): 217 (2012)
    Issue (Month): 3 ()
    Pages: 609-618

    as in new window
    Handle: RePEc:eee:ejores:v:217:y:2012:i:3:p:609-618

    Contact details of provider:
    Web page:

    Related research

    Keywords: IMRT; Beam angle optimization; Fluence map optimization; Radiation treatment; Local neighborhood search;


    No references listed on IDEAS
    You can help add them by filling out this form.


    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as in new window

    Cited by:
    1. H. Rocha & J. Dias & B. Ferreira & M. Lopes, 2013. "Selection of intensity modulated radiation therapy treatment beam directions using radial basis functions within a pattern search methods framework," Journal of Global Optimization, Springer, vol. 57(4), pages 1065-1089, December.
    2. Sauré, Antoine & Patrick, Jonathan & Tyldesley, Scott & Puterman, Martin L., 2012. "Dynamic multi-appointment patient scheduling for radiation therapy," European Journal of Operational Research, Elsevier, vol. 223(2), pages 573-584.


    This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.


    Access and download statistics


    When requesting a correction, please mention this item's handle: RePEc:eee:ejores:v:217:y:2012:i:3:p:609-618. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Zhang, Lei).

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If references are entirely missing, you can add them using this form.

    If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.