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Semiparametric regression analysis of panel count data with informative observation times

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  • Zhao, Xingqiu
  • Tong, Xingwei

Abstract

This paper discusses regression analysis of panel count data that arise naturally when recurrent events are considered. For the analysis of panel count data, most of the existing methods have assumed that observation times are completely independent of recurrent events or given covariates, which may not be true in practice. We propose a joint modeling approach that uses an unobserved random variable and a completely unspecified link function to characterize the correlations between the response variable and the observation times. For inference about regression parameters, estimating equation approaches are developed without involving any estimation for latent variables, and the asymptotic properties of the resulting estimators are established. In addition, a technique is provided for assessing the adequacy of the model. The performance of the proposed estimation procedures are evaluated by means of Monte Carlo simulations, and a data set from a bladder tumor study is analyzed as an illustrative example.

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  • Zhao, Xingqiu & Tong, Xingwei, 2011. "Semiparametric regression analysis of panel count data with informative observation times," Computational Statistics & Data Analysis, Elsevier, vol. 55(1), pages 291-300, January.
    • Handle: RePEc:eee:csdana:v:55:y:2011:i:1:p:291-300
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    References listed on IDEAS

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    1. Jianguo Sun, 2003. "A nonparametric test for panel count data," Biometrika, Biometrika Trust, vol. 90(1), pages 199-208, March.
    2. Jianguo Sun & Xingwei Tong & Xin He, 2007. "Regression Analysis of Panel Count Data with Dependent Observation Times," Biometrics, The International Biometric Society, vol. 63(4), pages 1053-1059, December.
    3. Ying Zhang & Mortaza Jamshidian, 2003. "The Gamma-Frailty Poisson Model for the Nonparametric Estimation of Panel Count Data," Biometrics, The International Biometric Society, vol. 59(4), pages 1099-1106, December.
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    6. J. Sun & L. J. Wei, 2000. "Regression analysis of panel count data with covariate‐dependent observation and censoring times," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 62(2), pages 293-302.
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    10. Chiung-Yu Huang & Mei-Cheng Wang, 2004. "Joint Modeling and Estimation for Recurrent Event Processes and Failure Time Data," Journal of the American Statistical Association, American Statistical Association, vol. 99, pages 1153-1165, December.
    11. D. Y. Lin & L. J. Wei & I. Yang & Z. Ying, 2000. "Semiparametric regression for the mean and rate functions of recurrent events," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 62(4), pages 711-730.
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    13. Lin D Y & Ying Z, 2001. "Semiparametric and Nonparametric Regression Analysis of Longitudinal Data," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 103-126, March.
    14. Balakrishnan, N. & Zhao, Xingqiu, 2010. "A nonparametric test for the equality of counting processes with panel count data," Computational Statistics & Data Analysis, Elsevier, vol. 54(1), pages 135-142, January.
    15. Stuart R. Lipsitz & Garrett M. Fitzmaurice & Joseph G. Ibrahim & Richard Gelber & Steven Lipshultz, 2002. "Parameter Estimation in Longitudinal Studies with Outcome-Dependent Follow-Up," Biometrics, The International Biometric Society, vol. 58(3), pages 621-630, September.
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    Citations

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    Cited by:

    1. Wang, Yijun & Wang, Weiwei & Zhao, Xiaobing, 2022. "Local logarithm partial likelihood estimation of panel count data model with an unknown link function," Computational Statistics & Data Analysis, Elsevier, vol. 166(C).
    2. Yang Li & Xin He & Haiying Wang & Jianguo Sun, 2016. "Regression analysis of longitudinal data with correlated censoring and observation times," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 22(3), pages 343-362, July.
    3. Wang, Weiwei & Wu, Xianyi & Zhao, Xiaobing & Zhou, Xian, 2018. "Robust variable selection of joint frailty model for panel count data," Journal of Multivariate Analysis, Elsevier, vol. 167(C), pages 60-78.
    4. Sy Han Chiou & Gongjun Xu & Jun Yan & Chiung‐Yu Huang, 2018. "Semiparametric estimation of the accelerated mean model with panel count data under informative examination times," Biometrics, The International Biometric Society, vol. 74(3), pages 944-953, September.
    5. Weiwei Wang & Yijun Wang & Xiaobing Zhao, 2022. "Semiparametric analysis of multivariate panel count data with nonlinear interactions," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 28(1), pages 89-115, January.
    6. Wei, Honglei & Zhang, Hongfan & Jiang, Hui & Huang, Lei, 2022. "On the semi-varying coefficient dynamic panel data model with autocorrelated errors," Computational Statistics & Data Analysis, Elsevier, vol. 173(C).
    7. Li, Yang & Zhao, Hui & Sun, Jianguo & Kim, KyungMann, 2014. "Nonparametric tests for panel count data with unequal observation processes," Computational Statistics & Data Analysis, Elsevier, vol. 73(C), pages 103-111.
    8. Li, Yang & He, Xin & Wang, Haiying & Zhang, Bin & Sun, Jianguo, 2015. "Semiparametric regression of multivariate panel count data with informative observation times," Journal of Multivariate Analysis, Elsevier, vol. 140(C), pages 209-219.
    9. Zhao, Xingqiu & Tong, Xingwei & Sun, Jianguo, 2013. "Robust estimation for panel count data with informative observation times," Computational Statistics & Data Analysis, Elsevier, vol. 57(1), pages 33-40.
    10. Hangjin Jiang & Wen Su & Xingqiu Zhao, 2020. "Robust estimation for panel count data with informative observation times and censoring times," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(1), pages 65-84, January.

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