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Combining quantitative trait loci analyses and microarray data: An empirical likelihood approach

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  • Wang, Dong
  • Chen, Song Xi

Abstract

Selective transcriptional profiling is an attractive approach for alleviating the high cost of genetical genomics research as it requires only a subset of individuals in the QTL mapping study for microarray experiments. Current statistical methods for this approach are based on parametric models that might not be appropriate for all experiments. To provide a nonparametric method for analyzing data obtained in selective transcriptional profiling studies, an empirical-likelihood-based inference is derived for multi-sample comparisons when information is available on surrogate variables. The results show that when testing for the association between the transcriptional abundance of a given gene and a known QTL, using relatively inexpensive trait data on extra individuals significantly improves the power for the proposed test.

Suggested Citation

  • Wang, Dong & Chen, Song Xi, 2009. "Combining quantitative trait loci analyses and microarray data: An empirical likelihood approach," Computational Statistics & Data Analysis, Elsevier, vol. 53(5), pages 1661-1673, March.
    • Handle: RePEc:eee:csdana:v:53:y:2009:i:5:p:1661-1673
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    References listed on IDEAS

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    1. F. Zou, 2002. "On empirical likelihood for a semiparametric mixture model," Biometrika, Biometrika Trust, vol. 89(1), pages 61-75, March.
    2. F. Zou, 2002. "A note on a partial empirical likelihood," Biometrika, Biometrika Trust, vol. 89(4), pages 958-961, December.
    3. Dong Wang & Dan Nettleton, 2006. "Identifying Genes Associated with a Quantitative Trait or Quantitative Trait Locus via Selective Transcriptional Profiling," Biometrics, The International Biometric Society, vol. 62(2), pages 504-514, June.
    4. Chen S.X. & Leung D.H.Y. & Qin J., 2003. "Information Recovery in a Study With Surrogate Endpoints," Journal of the American Statistical Association, American Statistical Association, vol. 98, pages 1052-1062, January.
    5. Adelchi Azzalini & Antonella Capitanio, 2003. "Distributions generated by perturbation of symmetry with emphasis on a multivariate skew t‐distribution," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 65(2), pages 367-389, May.
    6. Jin, Chunfang & Fine, Jason P. & Yandell, Brian S., 2007. "A Unified Semiparametric Framework for Quantitative Trait Loci Analyses, With Application to Spike Phenotypes," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 56-67, March.
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