IDEAS home Printed from https://ideas.repec.org/a/bpj/sagmbi/v8y2009i1n3.html
   My bibliography  Save this article

Sequential Analysis for Microarray Data Based on Sensitivity and Meta-Analysis

Author

Listed:
  • Marot Guillemette

    (INRA, Jouy-en-Josas, France)

  • Mayer Claus-Dieter

    (Biomathematics and Statistics Scotland)

Abstract

Motivation: Transcriptomic studies using microarray technology have become a standard tool in life sciences in the last decade. Nevertheless the cost of these experiments remains high and forces scientists to work with small sample sizes at the expense of statistical power. In many cases, little or no prior knowledge on the underlying variability is available, which would allow an accurate estimation of the number of samples (microarrays) required to answer a particular biological question of interest. We investigate sequential methods, also called group sequential or adaptive designs in the context of clinical trials, for microarray analysis. Through interim analyses at different stages of the experiment and application of a stopping rule a decision can be made as to whether more samples should be studied or whether the experiment has yielded enough information already.

Suggested Citation

  • Marot Guillemette & Mayer Claus-Dieter, 2009. "Sequential Analysis for Microarray Data Based on Sensitivity and Meta-Analysis," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 8(1), pages 1-33, January.
    • Handle: RePEc:bpj:sagmbi:v:8:y:2009:i:1:n:3
    DOI: 10.2202/1544-6115.1368
    as

    Download full text from publisher

    File URL: https://doi.org/10.2202/1544-6115.1368
    Download Restriction: For access to full text, subscription to the journal or payment for the individual article is required.
    File URL: https://libkey.io/10.2202/1544-6115.1368?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Walter Lehmacher & Gernot Wassmer, 1999. "Adaptive Sample Size Calculations in Group Sequential Trials," Biometrics, The International Biometric Society, vol. 55(4), pages 1286-1290, December.
    2. Allison, David B. & Gadbury, Gary L. & Heo, Moonseong & Fernandez, Jose R. & Lee, Cheol-Koo & Prolla, Tomas A. & Weindruch, Richard, 2002. "A mixture model approach for the analysis of microarray gene expression data," Computational Statistics & Data Analysis, Elsevier, vol. 39(1), pages 1-20, March.
    3. Smyth Gordon K, 2004. "Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 3(1), pages 1-28, February.
    4. Efron, Bradley, 2004. "Large-Scale Simultaneous Hypothesis Testing: The Choice of a Null Hypothesis," Journal of the American Statistical Association, American Statistical Association, vol. 99, pages 96-104, January.
    5. Zhijin Wu & Rafael Irizarry & Robert Gentleman & Francisco Martinez Murillo & Forrest Spencer, 2004. "A Model Based Background Adjustment for Oligonucleotide Expression Arrays," Johns Hopkins University Dept. of Biostatistics Working Paper Series 1001, Berkeley Electronic Press.
    6. Robin, Stephane & Bar-Hen, Avner & Daudin, Jean-Jacques & Pierre, Laurent, 2007. "A semi-parametric approach for mixture models: Application to local false discovery rate estimation," Computational Statistics & Data Analysis, Elsevier, vol. 51(12), pages 5483-5493, August.
    7. Zhijin Wu & Rafael A. Irizarry & Robert Gentleman & Francisco Martinez-Murillo & Forrest Spencer, 2004. "A Model-Based Background Adjustment for Oligonucleotide Expression Arrays," Journal of the American Statistical Association, American Statistical Association, vol. 99, pages 909-917, December.
    8. Mette Langaas & Bo Henry Lindqvist & Egil Ferkingstad, 2005. "Estimating the proportion of true null hypotheses, with application to DNA microarray data," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 67(4), pages 555-572, September.
    9. Loughin, Thomas M., 2004. "A systematic comparison of methods for combining p-values from independent tests," Computational Statistics & Data Analysis, Elsevier, vol. 47(3), pages 467-485, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nan Li & Matthew N. McCall & Zhijin Wu, 2017. "Establishing Informative Prior for Gene Expression Variance from Public Databases," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 9(1), pages 160-177, June.
    2. Montazeri Zahra & Yanofsky Corey M. & Bickel David R., 2010. "Shrinkage Estimation of Effect Sizes as an Alternative to Hypothesis Testing Followed by Estimation in High-Dimensional Biology: Applications to Differential Gene Expression," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 9(1), pages 1-33, June.
    3. Yu, Chang & Zelterman, Daniel, 2017. "A parametric model to estimate the proportion from true null using a distribution for p-values," Computational Statistics & Data Analysis, Elsevier, vol. 114(C), pages 105-118.
    4. Park, DoHwan & Park, Junyong & Zhong, Xiaosong & Sadelain, Michel, 2011. "Estimation of empirical null using a mixture of normals and its use in local false discovery rate," Computational Statistics & Data Analysis, Elsevier, vol. 55(7), pages 2421-2432, July.
    5. Mark A. van de Wiel & Kyung In Kim, 2007. "Estimating the False Discovery Rate Using Nonparametric Deconvolution," Biometrics, The International Biometric Society, vol. 63(3), pages 806-815, September.
    6. Bradley Efron, 2007. "Doing thousands of hypothesis tests at the same time," Metron - International Journal of Statistics, Dipartimento di Statistica, Probabilità e Statistiche Applicate - University of Rome, vol. 0(1), pages 3-21.
    7. Bickel David R., 2008. "Correcting the Estimated Level of Differential Expression for Gene Selection Bias: Application to a Microarray Study," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 7(1), pages 1-27, March.
    8. Robin, Stephane & Bar-Hen, Avner & Daudin, Jean-Jacques & Pierre, Laurent, 2007. "A semi-parametric approach for mixture models: Application to local false discovery rate estimation," Computational Statistics & Data Analysis, Elsevier, vol. 51(12), pages 5483-5493, August.
    9. Shigeyuki Matsui & Hisashi Noma, 2011. "Estimating Effect Sizes of Differentially Expressed Genes for Power and Sample-Size Assessments in Microarray Experiments," Biometrics, The International Biometric Society, vol. 67(4), pages 1225-1235, December.
    10. Rinku Sharma & Garima Singh & Sudeepto Bhattacharya & Ashutosh Singh, 2018. "Comparative transcriptome meta-analysis of Arabidopsis thaliana under drought and cold stress," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-18, September.
    11. Jin-Xing Liu & Yong Xu & Chun-Hou Zheng & Yi Wang & Jing-Yu Yang, 2012. "Characteristic Gene Selection via Weighting Principal Components by Singular Values," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-10, July.
    12. Alexander Kaever & Manuel Landesfeind & Kirstin Feussner & Burkhard Morgenstern & Ivo Feussner & Peter Meinicke, 2014. "Meta-Analysis of Pathway Enrichment: Combining Independent and Dependent Omics Data Sets," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-12, February.
    13. Han, Bing & Dalal, Siddhartha R., 2012. "A Bernstein-type estimator for decreasing density with application to p-value adjustments," Computational Statistics & Data Analysis, Elsevier, vol. 56(2), pages 427-437.
    14. He, Yi & Pan, Wei & Lin, Jizhen, 2006. "Cluster analysis using multivariate normal mixture models to detect differential gene expression with microarray data," Computational Statistics & Data Analysis, Elsevier, vol. 51(2), pages 641-658, November.
    15. Long Qu & Dan Nettleton & Jack C. M. Dekkers, 2012. "Improved Estimation of the Noncentrality Parameter Distribution from a Large Number of t-Statistics, with Applications to False Discovery Rate Estimation in Microarray Data Analysis," Biometrics, The International Biometric Society, vol. 68(4), pages 1178-1187, December.
    16. Sigrun Helga Lund & Daniel Fannar Gudbjartsson & Thorunn Rafnar & Asgeir Sigurdsson & Sigurjon Axel Gudjonsson & Julius Gudmundsson & Kari Stefansson & Gunnar Stefansson, 2014. "A Method for Detecting Long Non-Coding RNAs with Tiled RNA Expression Microarrays," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-9, June.
    17. Cheng, Cheng, 2009. "Internal validation inferences of significant genomic features in genome-wide screening," Computational Statistics & Data Analysis, Elsevier, vol. 53(3), pages 788-800, January.
    18. Krishanpal Anamika & Àkos Gyenis & Laetitia Poidevin & Olivier Poch & Làszlò Tora, 2012. "RNA Polymerase II Pausing Downstream of Core Histone Genes Is Different from Genes Producing Polyadenylated Transcripts," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-14, June.
    19. Xiang, Qinfang & Edwards, Jode & Gadbury, Gary L., 2006. "Interval estimation in a finite mixture model: Modeling P-values in multiple testing applications," Computational Statistics & Data Analysis, Elsevier, vol. 51(2), pages 570-586, November.
    20. Lei Zhang & Linlin Wang & Pu Tian & Suyan Tian, 2016. "Identification of Genes Discriminating Multiple Sclerosis Patients from Controls by Adapting a Pathway Analysis Method," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-13, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bpj:sagmbi:v:8:y:2009:i:1:n:3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Peter Golla (email available below). General contact details of provider: https://www.degruyter.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.