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Simplex Mixed‐Effects Models for Longitudinal Proportional Data

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  • ZHENGUO QIU
  • PETER X.‐K. SONG
  • MING TAN

Abstract

. Continuous proportional outcomes are collected from many practical studies, where responses are confined within the unit interval (0,1). Utilizing Barndorff‐Nielsen and Jørgensen's simplex distribution, we propose a new type of generalized linear mixed‐effects model for longitudinal proportional data, where the expected value of proportion is directly modelled through a logit function of fixed and random effects. We establish statistical inference along the lines of Breslow and Clayton's penalized quasi‐likelihood (PQL) and restricted maximum likelihood (REML) in the proposed model. We derive the PQL/REML using the high‐order multivariate Laplace approximation, which gives satisfactory estimation of the model parameters. The proposed model and inference are illustrated by simulation studies and a data example. The simulation studies conclude that the fourth order approximate PQL/REML performs satisfactorily. The data example shows that Aitchison's technique of the normal linear mixed model for logit‐transformed proportional outcomes is not robust against outliers.

Suggested Citation

  • Zhenguo Qiu & Peter X.‐K. Song & Ming Tan, 2008. "Simplex Mixed‐Effects Models for Longitudinal Proportional Data," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 35(4), pages 577-596, December.
    • Handle: RePEc:bla:scjsta:v:35:y:2008:i:4:p:577-596
    DOI: 10.1111/j.1467-9469.2008.00603.x
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    References listed on IDEAS

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    1. Barndorff-Nielsen, O. E. & Jørgensen, B., 1991. "Some parametric models on the simplex," Journal of Multivariate Analysis, Elsevier, vol. 39(1), pages 106-116, October.
    2. Peter Xue-Kun Song & Ming Tan, 2000. "Marginal Models for Longitudinal Continuous Proportional Data," Biometrics, The International Biometric Society, vol. 56(2), pages 496-502, June.
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    Cited by:

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    2. Jay Verkuilen & Michael Smithson, 2012. "Mixed and Mixture Regression Models for Continuous Bounded Responses Using the Beta Distribution," Journal of Educational and Behavioral Statistics, , vol. 37(1), pages 82-113, February.
    3. Zhao, Weihua & Lian, Heng & Zhang, Riquan & Lai, Peng, 2016. "Estimation and variable selection for proportional response data with partially linear single-index models," Computational Statistics & Data Analysis, Elsevier, vol. 96(C), pages 40-56.
    4. Wenting Liu & Huiqiong Li & Anmin Tang & Zixin Cui, 2023. "Bayesian Joint Modeling Analysis of Longitudinal Proportional and Survival Data," Mathematics, MDPI, vol. 11(16), pages 1-17, August.
    5. Hui Song & Yingwei Peng & Dongsheng Tu, 2017. "Jointly modeling longitudinal proportional data and survival times with an application to the quality of life data in a breast cancer trial," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(2), pages 183-206, April.
    6. Jaeun Choi & Jianwen Cai & Donglin Zeng, 2017. "Penalized Likelihood Approach for Simultaneous Analysis of Survival Time and Binary Longitudinal Outcome," Sankhya B: The Indian Journal of Statistics, Springer;Indian Statistical Institute, vol. 79(2), pages 190-216, November.
    7. Patrícia L. Espinheira & Alisson Oliveira Silva, 2020. "Residual and influence analysis to a general class of simplex regression," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 29(2), pages 523-552, June.
    8. Tourani-Farani, Fahimeh & Kazemi, Iraj, 2022. "Transformed mixed-effects modeling of correlated bounded and positive data with a novel multivariate generalized Johnson distribution," Journal of Multivariate Analysis, Elsevier, vol. 190(C).
    9. Shilan Li & Jianxin Shi & Paul Albert & Hong-Bin Fang, 2022. "Dependence Structure Analysis and Its Application in Human Microbiome," Mathematics, MDPI, vol. 11(1), pages 1-14, December.

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