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Bounds on causal effects in three-arm trials with non-compliance


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  • Jing Cheng
  • Dylan S. Small
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    The paper considers the analysis of three-arm randomized trials with non-compliance. In these trials, the average causal effects of treatments within principal strata of compliance behaviour are of interest for better understanding the effect of the treatment. Unfortunately, even with the usual assumptions, the average causal effects of treatments within principal strata are not point identified. However, the observable data do provide useful information on the bounds of the identification regions of the parameters of interest. Under two sets of assumptions, we derive sharp bounds for the causal effects within principal strata for binary outcomes and construct confidence intervals to cover the identification regions. The methods are illustrated by an analysis of data from a randomized study of treatments for alcohol dependence. Copyright 2006 Royal Statistical Society.

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    Bibliographic Info

    Article provided by Royal Statistical Society in its journal Journal of the Royal Statistical Society: Series B (Statistical Methodology).

    Volume (Year): 68 (2006)
    Issue (Month): 5 ()
    Pages: 815-836

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    Handle: RePEc:bla:jorssb:v:68:y:2006:i:5:p:815-836

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    Cited by:
    1. Martin Huber & Giovanni Mellace, 2010. "Sharp IV bounds on average treatment effects under endogeneity and noncompliance," University of St. Gallen Department of Economics working paper series 2010 2010-31, Department of Economics, University of St. Gallen.
    2. Chiba, Yasutaka, 2012. "A note on bounds for the causal infectiousness effect in vaccine trials," Statistics & Probability Letters, Elsevier, vol. 82(7), pages 1422-1429.
    3. Chiba, Yasutaka, 2012. "Bounds on the complier average causal effect in randomized trials with noncompliance," Statistics & Probability Letters, Elsevier, vol. 82(7), pages 1352-1357.
    4. VanderWeele, Tyler J., 2008. "Simple relations between principal stratification and direct and indirect effects," Statistics & Probability Letters, Elsevier, vol. 78(17), pages 2957-2962, December.
    5. Imai, Kosuke, 2008. "Sharp bounds on the causal effects in randomized experiments with "truncation-by-death"," Statistics & Probability Letters, Elsevier, vol. 78(2), pages 144-149, February.


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